Electrophoresis-Based Approach for Characterizing Dendrimer–Protein Interactions: A Proof-of-Concept Study

Improving the clinical translation of nanomedicine requires better knowledge about how nanoparticles interact with biological environments. As researchers are recognizing the importance of understanding the protein corona and characterizing how nanocarriers respond in biological systems, new tools a...

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Bibliographic Details
Published in:ACS biomaterials science & engineering 2024-06, Vol.10 (6), p.3747-3758
Main Authors: Douglas-Green, Simone A., Aleman, Juan A., Hammond, Paula T.
Format: Article
Language:English
Subjects:
Bio-interactions and Biocompatibility
Dendrimers - chemistry
Dendrimers - metabolism
Electrophoresis
Humans
Nanoparticles - chemistry
Proof of Concept Study
Protein Binding
Proteins - chemistry
Proteins - metabolism
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Summary:Improving the clinical translation of nanomedicine requires better knowledge about how nanoparticles interact with biological environments. As researchers are recognizing the importance of understanding the protein corona and characterizing how nanocarriers respond in biological systems, new tools and techniques are needed to analyze nanocarrier–protein interactions, especially for smaller size (
ISSN:2373-9878
2373-9878
DOI:10.1021/acsbiomaterials.3c01579