Additive association of blood pressure and short stature with stroke incidence in 450,000 Japanese adults: the Shizuoka study

Short stature was suggested to be a risk factor for cardiovascular events. Because short stature increases central blood pressure, this study aimed to investigate a longitudinal association between short stature, blood pressure, and incidence of cardiovascular disease by the analysis of insurance-ba...

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Bibliographic Details
Published in:Hypertension research 2024-08, Vol.47 (8), p.2075-2085
Main Authors: Tabara, Yasuharu, Shoji-Asahina, Aya, Ogawa, Aya, Sato, Yoko
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood Pressure - physiology
Body Height
East Asian People
Female
Geriatrics/Gerontology
Health Promotion and Disease Prevention
Humans
Hypertension - epidemiology
Incidence
Internal Medicine
Japan - epidemiology
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Obstetrics/Perinatology/Midwifery
Public Health
Risk Factors
Stroke - epidemiology
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Summary:Short stature was suggested to be a risk factor for cardiovascular events. Because short stature increases central blood pressure, this study aimed to investigate a longitudinal association between short stature, blood pressure, and incidence of cardiovascular disease by the analysis of insurance-based real-world dataset. We analyzed data from 463,844 adults aged 40 or older with a mean age of 66.7 enrolled in National Health Insurance, excluding individuals who experienced a stroke or myocardial infarction, or required long-term care. Data from annual health checkups were used to obtain baseline clinical information. Comorbidities and incidences of stroke and myocardial infarction were obtained from the insurance data. During a 5.5-year follow-up period, we observed 11,027 cases of stroke. Adults of a short stature exhibited a higher incidence rate in both men (≤155 cm: 99.7, >175 cm: 24.4) and women (≤140 cm: 85.9, >160 cm: 13.7). Although those in the short stature group had higher blood pressure, and often took antihypertensive drugs, the inverse association between height and stroke incidence was independent of these factors (hazard ratio for 5 cm shorter in height; men: 1.06 [1.03–1.09], women: 1.11 [1.06–1.13]). Short stature and blood pressure showed additive association with stoke incidence (log-rank p  
ISSN:0916-9636
1348-4214
1348-4214
DOI:10.1038/s41440-024-01702-x