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Impact of thyroid carcinoma invasion of recurrent laryngeal nerve on cervical lymph node metastasis

Purpose Papillary thyroid carcinoma (PTC) has a favorable prognosis. However, involvement of the recurrent laryngeal nerve (RLN) significantly increases the risk of recurrence. RLN invasion was an important factor in determining the extent of thyroid surgery. The purpose of this study was to compare...

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Bibliographic Details
Published in:Endocrine 2024-11, Vol.86 (2), p.654-663
Main Authors: Zhu, Feng, Shen, YiBin, Zhu, LiXian, Chen, LinHui, Li, FuQiang, Xie, XiaoJun, Wu, YiJun
Format: Article
Language:English
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Summary:Purpose Papillary thyroid carcinoma (PTC) has a favorable prognosis. However, involvement of the recurrent laryngeal nerve (RLN) significantly increases the risk of recurrence. RLN invasion was an important factor in determining the extent of thyroid surgery. The purpose of this study was to compare clinicopathologic features and characterize risk factors of central and lateral lymph node metastasis (LLNM) of RLN invasion in patients with PTC. Methods A retrospective review was conducted of 130 patients with PTCs who had exclusive tumor involvement of the RLN at our institution between January 2014 and February 2019. All patients underwent total thyroidectomy and high-dose radioactive iodine (RAI) therapy. The clinicopathologic factors and prognostic outcomes of the patients with solitary and multiple RLN involvements were compared. Kaplan–Meier method was performed to compare the outcomes of tumor recurrence. Univariate and multivariate logistic regression analyses were used to identify risk factors associated with LLNM. Results The invasion of the RLN was similar on both sides, with 58.5% on the right, 40.0% on the left, and 1.5% on both sides. Significant differences were observed in tumor size ( p  
ISSN:1559-0100
1559-0100
DOI:10.1007/s12020-024-03879-0