Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia

The term “juvenile-like (inflammatory/hyperplastic) mucosal polyps” (JLIHMP) has been recently introduced to describe a spectrum of polypoid lesions in patients with neurofibromatosis type 1 (NF-1). Due to the scarce number of reported cases and histopathological similarities with entities such as s...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2024-05, Vol.484 (5), p.865-868
Main Authors: Enea, Diana, Dray, Xavier, Guillerm, Erell, Guilloux, Antoine, Yver, Matthieu, Cervera, Pascale, Svrcek, Magali
Format: Article
Language:English
Subjects:
Brief Report
Colon
Colonoscopy
Dysplasia
Endoscopy
Female
Genetic disorders
Histopathology
Humans
Hyperplasia - pathology
Inflammation
Inflammation - pathology
Male
Medicine
Medicine & Public Health
Mutation
Neurofibromatosis
Neurofibromatosis 1 - complications
Neurofibromatosis 1 - diagnosis
Neurofibromatosis 1 - pathology
Pathology
Patients
Polyps
Polyps - pathology
Recklinghausen's disease
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Description
Summary:The term “juvenile-like (inflammatory/hyperplastic) mucosal polyps” (JLIHMP) has been recently introduced to describe a spectrum of polypoid lesions in patients with neurofibromatosis type 1 (NF-1). Due to the scarce number of reported cases and histopathological similarities with entities such as sporadic/syndromic juvenile polyps or inflammatory fibroid polyps, this entity remains a subject of debate. We describe herein a case of multiple JLIHMPs in a patient with NF-1, and we document the presence of low-grade dysplasia within one of these polyps.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-024-03769-w