The role of time to positive blood cultures in enhancing the predictive capability of DENOVA score for diagnosing infective endocarditis in patients with Enterococcus faecalis bacteremia

DENOVA-score is useful to stratify the risk of infective endocarditis (IE) in Enterococcus faecalis bacteremia. Recently, time to positive (TTP) of blood cultures has also been related with a higher risk of IE. The objective was to evaluate DENOVA- score with TTP to improve its specificity. We perfo...

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Published in:European journal of clinical microbiology & infectious diseases 2024-07, Vol.43 (7), p.1481-1486
Main Authors: Pérez-Rodríguez, M Teresa, Lima, Olalla, Garrido, Martín, Rincón, Anniris, Martínez-Lamas, Lucía, Pérez-González, Alexandre, Araújo, Alejandro, Amoedo, Antía, Sousa, Adrián, López, Ana, Cabrera, Xurxo, Rubianes, Martín
Format: Article
Language:English
Subjects:
Bacteremia
Biomedical and Life Sciences
Biomedicine
Blood
Brief Report
Catheters
Endocarditis
Enterococcus faecalis
Infectious diseases
Internal Medicine
Medical Microbiology
Mortality
Variables
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Summary:DENOVA-score is useful to stratify the risk of infective endocarditis (IE) in Enterococcus faecalis bacteremia. Recently, time to positive (TTP) of blood cultures has also been related with a higher risk of IE. The objective was to evaluate DENOVA- score with TTP to improve its specificity. We performed a retrospective, case–control study in adult patients with E. faecalis bacteremia. Thirty-nine patients with definite E. faecalis IE and 82 with E. faecalis bacteremia were included. The addition of a TTP ≤ 8 h to DENOVA-score did not improve the diagnostic accuracy of this score.
ISSN:0934-9723
1435-4373
1435-4373
DOI:10.1007/s10096-024-04843-6