Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells

Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2024-03, Vol.37 (2), p.307-314
Main Authors: Wijianto, Diski Wahyu, Wahyuni, Arifah Sri, Wardani, Rizkiananda, Nugraheni, Ambar Yunita, Abu Bakar, Fazleen Izzany
Format: Article
Language:English
Subjects:
Alcohol
Alcohol, Denatured
Animals
Blood Glucose - drug effects
Blood Glucose - metabolism
Care and treatment
Complications and side effects
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Ethanol - chemistry
Glucose metabolism
Health aspects
Hyperglycemia
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Kidney - drug effects
Kidney - metabolism
Liver - drug effects
Liver - metabolism
Male
Oryza - chemistry
Oxidative stress
Pancreas - drug effects
Pancreas - metabolism
Pancreas - pathology
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Rats
Rats, Wistar
Sulfonylurea Compounds - pharmacology
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Summary:Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (
ISSN:1011-601X
DOI:10.36721/PJPS.2024.37.2.REG.307-314.1