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Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran...
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| Published in: | Pakistan journal of pharmaceutical sciences 2024-03, Vol.37 (2), p.307-314 |
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| Format: | Article |
| Language: | English |
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| container_end_page | 314 |
| container_issue | 2 |
| container_start_page | 307 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 37 |
| creator | Wijianto, Diski Wahyu Wahyuni, Arifah Sri Wardani, Rizkiananda Nugraheni, Ambar Yunita Abu Bakar, Fazleen Izzany |
| description | Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal ( |
| doi_str_mv | 10.36721/PJPS.2024.37.2.REG.307-314.1 |
| format | article |
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Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2024.37.2.REG.307-314.1</identifier><identifier>PMID: 38767097</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Alcohol ; Alcohol, Denatured ; Animals ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Care and treatment ; Complications and side effects ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - drug therapy ; Ethanol - chemistry ; Glucose metabolism ; Health aspects ; Hyperglycemia ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - pharmacology ; Kidney - drug effects ; Kidney - metabolism ; Liver - drug effects ; Liver - metabolism ; Male ; Oryza - chemistry ; Oxidative stress ; Pancreas - drug effects ; Pancreas - metabolism ; Pancreas - pathology ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Sulfonylurea Compounds - pharmacology</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2024-03, Vol.37 (2), p.307-314</ispartof><rights>COPYRIGHT 2024 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38767097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wijianto, Diski Wahyu</creatorcontrib><creatorcontrib>Wahyuni, Arifah Sri</creatorcontrib><creatorcontrib>Wardani, Rizkiananda</creatorcontrib><creatorcontrib>Nugraheni, Ambar Yunita</creatorcontrib><creatorcontrib>Abu Bakar, Fazleen Izzany</creatorcontrib><title>Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells.</description><subject>Alcohol</subject><subject>Alcohol, Denatured</subject><subject>Animals</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Ethanol - chemistry</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - isolation & purification</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Oryza - chemistry</subject><subject>Oxidative stress</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - pathology</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sulfonylurea Compounds - pharmacology</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNptkV1r1UAQhvdCsbX6F2RBBC9M3M9sclnKsa0ULH6Ad2E_JqdrN7vHzaa0_6U_tomnCkKZi4F5n5l5mUHoHSU1bxSjHy8_X36rGWGi5qpm9dfNac2JqjgVNX2GDimhtGoI_XmAXk7TL0Ia0XXdC3TAW9Uo0qlDdL-50WHWxaeI04DLFWCbRuPjv5IJ2l7j7C1gk3XEUK50TAHDbcnaFqyjw9vgR9j57B1gH3EGN1sft0tvSqs62zTBH3KXUwFbVvHauwh3H3DwN5D3oo42w7LZYgshTK_Q80GHCV4_5iP049Pm-8lZdfHl9Pzk-KLaMtWWinUKTKul0nLgWhpOaTtYzYhkzg6CWMtazZUwXUuEkU4y29FGOjOA4CAJP0Lv93MXd79nmEo_-ml1oCOkeeo5kYooSalc0Ld7dKsD9D4Oab3CivfHqmOi7VpBF6p-glrCwehtijD4pf5fw5tHB7MZwfW77Eed7_q_j-IPiz2YAA</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Wijianto, Diski Wahyu</creator><creator>Wahyuni, Arifah Sri</creator><creator>Wardani, Rizkiananda</creator><creator>Nugraheni, Ambar Yunita</creator><creator>Abu Bakar, Fazleen Izzany</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20240301</creationdate><title>Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells</title><author>Wijianto, Diski Wahyu ; Wahyuni, Arifah Sri ; Wardani, Rizkiananda ; Nugraheni, Ambar Yunita ; Abu Bakar, Fazleen Izzany</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-297eb8a57a5f3a5b3118fca2052dcf40cc28a374b9804b5d52c9165dbfe43e503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alcohol</topic><topic>Alcohol, Denatured</topic><topic>Animals</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Ethanol - chemistry</topic><topic>Glucose metabolism</topic><topic>Health aspects</topic><topic>Hyperglycemia</topic><topic>Hypoglycemic Agents - isolation & purification</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Oryza - chemistry</topic><topic>Oxidative stress</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - pathology</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sulfonylurea Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wijianto, Diski Wahyu</creatorcontrib><creatorcontrib>Wahyuni, Arifah Sri</creatorcontrib><creatorcontrib>Wardani, Rizkiananda</creatorcontrib><creatorcontrib>Nugraheni, Ambar Yunita</creatorcontrib><creatorcontrib>Abu Bakar, Fazleen Izzany</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wijianto, Diski Wahyu</au><au>Wahyuni, Arifah Sri</au><au>Wardani, Rizkiananda</au><au>Nugraheni, Ambar Yunita</au><au>Abu Bakar, Fazleen Izzany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>37</volume><issue>2</issue><spage>307</spage><epage>314</epage><pages>307-314</pages><issn>1011-601X</issn><abstract>Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>38767097</pmid><doi>10.36721/PJPS.2024.37.2.REG.307-314.1</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Alcohol Alcohol, Denatured Animals Blood Glucose - drug effects Blood Glucose - metabolism Care and treatment Complications and side effects Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Ethanol - chemistry Glucose metabolism Health aspects Hyperglycemia Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Oryza - chemistry Oxidative stress Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Rats, Wistar Sulfonylurea Compounds - pharmacology |
| title | Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
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