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Advances in Crystallization and Precipitation Technologies for Biotherapeutics

Royo et al delve into efforts to develop platform technologies for protein crystallization/precipitation, emphasizing the critical role of modeling in improving process understanding. They present the fundamental theory of crystallization/precipitation and the challenges associated with it. They als...

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Bibliographic Details
Published in:Chemical engineering progress 2024-05, Vol.120 (5), p.25-31
Main Authors: Royo, Maria del Carme Pons, Guo, Jing, Bal, Vivekananda, Hong, Moo Sun, Barone, Paul W, Springs, Stacy L, Sinskey, Anthony J, Stelzer, Torsten, Trout, Bernhardt L, Myerson, Allan S, Braatz, Richard D
Format: Magazinearticle
Language:English
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Summary:Royo et al delve into efforts to develop platform technologies for protein crystallization/precipitation, emphasizing the critical role of modeling in improving process understanding. They present the fundamental theory of crystallization/precipitation and the challenges associated with it. They also review case studies focusing on the crystallization of monoclonal antibodies, showcasing successful applications of molecular modeling to assess the ease of crystallization, and employing a systematic approach using a droplet-based automated evaporative system for optimal scale-up. Furthermore, they demonstrate an integrated experimental and modeling approach for purifying adeno-associated virus (AAV) vectors, highlighting the unique challenges and potential benefits of this method in the context of AAV vectors.
ISSN:0360-7275
1945-0710