Neural pathways for reward and relief promote fentanyl addiction

Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal. Neural mechanisms that reinforce use of potent synthetic opioid found.

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Bibliographic Details
Published in:Nature (London) 2024-06, Vol.630 (8015), p.38-39
Main Authors: Heilig, Markus, Petrella, Michele
Format: Article
Language:English
Subjects:
631/378
692/698/1688/64
692/699/476
Animals
Behavior, Addictive - psychology
Fentanyl - pharmacology
Humanities and Social Sciences
Humans
Mice
multidisciplinary
Neural Pathways - drug effects
News And Views
Opioid-Related Disorders - drug therapy
Reward
Science
Citations: Items that this one cites
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Description
Summary:Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal. Neural mechanisms that reinforce use of potent synthetic opioid found.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-024-01361-5