Association of handgrip strength with nutritional status and clinical outcomes in hospitalized pediatric patients

• Published in: Clinical nutrition ESPEN 2024-06, Vol.61, p.413-419
• Main Authors: Luz, Gabriela Duarte, Pereira, Danielly Steffen, Minho, Jéssica Batista, Dias, Patrícia Daniele Chrisóstomo, Moraes, Emilly Santos, da Silva, Vitória Mello, Dutra, Angélica Paula Barbosa Silva, Silva, Flávia Moraes, Dalle Molle, Roberta
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Body Composition; Body Mass Index; Child; Children; Cohort Studies; Female; Hand Strength; Handgrip strength; Hospital stay; Hospitalization; Humans; Length of Stay; Male; Malnutrition; Nutrition Assessment; Nutritional assessment; Nutritional Status
• ISSN: 2405-4577; 2405-4577
• DOI: 10.1016/j.clnesp.2024.04.008

Malnutrition in children and adolescents is prevalent at hospital admission and the incidence increases with length of stay. Malnourished patients have loss of muscle mass and strength, compromising their functionality. Handgrip strength (HGS) is a nutritional marker understudied in pediatrics although it is capable of detecting nutritional deprivation before changes in body composition are observed. Therefore, this study aimed to evaluate the association between reduced HGS at hospital admission, compromised nutritional status and worse clinical outcomes of pediatric patients. Cohort study conducted with patients aged 6–18 years admitted to a pediatric ward. Nutritional status was assessed in the first 48 h of hospital admission using the z-score of height for age (H/A) and body mass index for age (BMI/A), percentile of mid-arm muscle circumference for age (MAMC/A) and the pediatric global subjective nutritional assessment (SGNA). HGS was measured using a digital dynamometer and considered reduced when the maximum value of three measurements was below the 5th percentile for sex and age. The clinical outcomes analyzed were length of hospital stay and frequency of readmission within 3 months after hospital discharge. A total of 135 patients were evaluated (median age 10.9 years, 55.6% male) and 17.8% had reduced HGS. Patients with reduced HGS had lower H/A z-score (−0.50 vs 0.22, p = 0.012) and a higher frequency of reduced MAMC when compared to those with normal HGS (8% vs 13%, p = 0.007). Reduced HGS was not associated with malnutrition (OR = 0.63; 95%CI 0.23–1.77), prolonged hospital stay (OR = 1.89; 95%CI 0.72–4.92) or readmission to hospital 3 months after hospital discharge (OR = 1.82; 95%CI 0.67–4.93), in a model adjusted for the clinical condition. Reduced HGS was not a predictor of malnutrition and clinical outcomes. However, it was associated with lower H/A Z-score and MAMC/A percentile values and can be used as a complementary measure in the nutritional status assessment of hospitalized pediatric patients.