Influence of E‐cadherin deficiency on the dendrite morphology of Langerhans cells

The expression of E‐cadherin on Langerhans cells (LC) is required for adequate dendrite intercalation between epidermal keratinocytes. Upon disruption of epidermal homeostasis by tape stripping, E‐cadherin competent LC extend dendrites reaching up to the epidermal surface, while E‐cad deficient LC l...

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Bibliographic Details
Published in:European journal of immunology 2024-09, Vol.54 (9), p.e2350797-n/a
Main Authors: Dorn, Britta, Ruhland, Cindy, Kunz, Stefanie, Martin, Stefan F., Jakob, Thilo
Format: Article
Language:English
Subjects:
Adherens
Animals
Cadherin
Cadherins
Cadherins - genetics
Cadherins - metabolism
Dendrites
Dendrites - metabolism
Epidermis - metabolism
Homeostasis
Keratinocytes
Keratinocytes - metabolism
Langerhans cells
Langerhans Cells - immunology
Langerhans Cells - metabolism
Mice
Mice, Knockout
Migration
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Description
Summary:The expression of E‐cadherin on Langerhans cells (LC) is required for adequate dendrite intercalation between epidermal keratinocytes. Upon disruption of epidermal homeostasis by tape stripping, E‐cadherin competent LC extend dendrites reaching up to the epidermal surface, while E‐cad deficient LC lack this ability.
ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202350797