Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae

Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2 ,4 -N-...

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Published in:Natural product research 2024-05, p.1-6
Main Authors: Sharma, Rahul, Arumugam, Neelakantan
Format: Article
Language:English
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Summary:Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2 ,4 -N-isobutyl-undeca-2,4-diene-8,10-diynamide ( ) and 2 ,4 ,8 ,10 -N-isobutyl-dodeca-2,4,8,10-tetraenamide ( )] of exhibit biocidal action against and larvae. The LC for and were 44.19 and 18.28 ppm against larvae, and 30.89 and 11.75 ppm against larvae, respectively. We further observed that the chain length, degree of unsaturation, and terminal methylation influence the larvicidal efficacy of N-alkylamides. HPLC-assisted quantification revealed that the content of both (19.01 mg/g) and (68.55 mg/g) was maximum in the flowers of . Thus, this study concludes that N-alkylamides are promising alternatives to control mosquito larvae and can be used as standard for quantitation in test samples.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2024.2357666