Loading…
Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae
Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2 ,4 -N-...
Saved in:
| Published in: | Natural product research 2024-05, p.1-6 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c257t-39ef97bd399a2307b1f0a9e923bee4aec31b9c5efffe89b7f10ba1b21fa366203 |
| container_end_page | 6 |
| container_issue | |
| container_start_page | 1 |
| container_title | Natural product research |
| container_volume | |
| creator | Sharma, Rahul Arumugam, Neelakantan |
| description | Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2
,4
-N-isobutyl-undeca-2,4-diene-8,10-diynamide (
) and 2
,4
,8
,10
-N-isobutyl-dodeca-2,4,8,10-tetraenamide (
)] of
exhibit biocidal action against
and
larvae. The LC
for
and
were 44.19 and 18.28 ppm against
larvae, and 30.89 and 11.75 ppm against
larvae, respectively. We further observed that the chain length, degree of unsaturation, and terminal methylation influence the larvicidal efficacy of N-alkylamides. HPLC-assisted quantification revealed that the content of both
(19.01 mg/g) and
(68.55 mg/g) was maximum in the flowers of
. Thus, this study concludes that N-alkylamides are promising alternatives to control mosquito larvae and can be used as standard for quantitation in test samples. |
| doi_str_mv | 10.1080/14786419.2024.2357666 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3059257108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3059257108</sourcerecordid><originalsourceid>FETCH-LOGICAL-c257t-39ef97bd399a2307b1f0a9e923bee4aec31b9c5efffe89b7f10ba1b21fa366203</originalsourceid><addsrcrecordid>eNo9kMtOwzAQRS0EoqXwCSAv2aT4kcTxslS8pAo2sI4mzrgyOEkbJ4j8PSltWc1D985cHUKuOZtzlrE7HqssjbmeCybiuZCJStP0hEx3-yiNhTr977mekIsQPhkTPEmSczKRmVJaazEl5t41xpXgKVrrDJiBNpY2Hq2rnaGvEfivwUPlSgwU1uDq0NEF_k24Hjado1CXdNl7_KHb3tXbHi0E46DrA_XQfgNekjMLPuDVoc7Ix-PD-_I5Wr09vSwXq8iIRHWR1Gi1KkqpNQjJVMEtA41ayAIxBjSSF9okY06LmS6U5awAXghuQaapYHJGbvd3N20zxghdXrlg0HuoselDLlmix08jvlGa7KWmbUJo0eab1lXQDjln-Y5vfuSb7_jmB76j7-bwoi8qLP9dR6DyF8Etd6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3059257108</pqid></control><display><type>article</type><title>Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae</title><source>Taylor and Francis Science and Technology Collection</source><creator>Sharma, Rahul ; Arumugam, Neelakantan</creator><creatorcontrib>Sharma, Rahul ; Arumugam, Neelakantan</creatorcontrib><description>Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2
,4
-N-isobutyl-undeca-2,4-diene-8,10-diynamide (
) and 2
,4
,8
,10
-N-isobutyl-dodeca-2,4,8,10-tetraenamide (
)] of
exhibit biocidal action against
and
larvae. The LC
for
and
were 44.19 and 18.28 ppm against
larvae, and 30.89 and 11.75 ppm against
larvae, respectively. We further observed that the chain length, degree of unsaturation, and terminal methylation influence the larvicidal efficacy of N-alkylamides. HPLC-assisted quantification revealed that the content of both
(19.01 mg/g) and
(68.55 mg/g) was maximum in the flowers of
. Thus, this study concludes that N-alkylamides are promising alternatives to control mosquito larvae and can be used as standard for quantitation in test samples.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2024.2357666</identifier><identifier>PMID: 38779992</identifier><language>eng</language><publisher>England</publisher><ispartof>Natural product research, 2024-05, p.1-6</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c257t-39ef97bd399a2307b1f0a9e923bee4aec31b9c5efffe89b7f10ba1b21fa366203</cites><orcidid>0000-0002-1287-7235 ; 0000-0002-0762-8146</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38779992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Rahul</creatorcontrib><creatorcontrib>Arumugam, Neelakantan</creatorcontrib><title>Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2
,4
-N-isobutyl-undeca-2,4-diene-8,10-diynamide (
) and 2
,4
,8
,10
-N-isobutyl-dodeca-2,4,8,10-tetraenamide (
)] of
exhibit biocidal action against
and
larvae. The LC
for
and
were 44.19 and 18.28 ppm against
larvae, and 30.89 and 11.75 ppm against
larvae, respectively. We further observed that the chain length, degree of unsaturation, and terminal methylation influence the larvicidal efficacy of N-alkylamides. HPLC-assisted quantification revealed that the content of both
(19.01 mg/g) and
(68.55 mg/g) was maximum in the flowers of
. Thus, this study concludes that N-alkylamides are promising alternatives to control mosquito larvae and can be used as standard for quantitation in test samples.</description><issn>1478-6419</issn><issn>1478-6427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRS0EoqXwCSAv2aT4kcTxslS8pAo2sI4mzrgyOEkbJ4j8PSltWc1D985cHUKuOZtzlrE7HqssjbmeCybiuZCJStP0hEx3-yiNhTr977mekIsQPhkTPEmSczKRmVJaazEl5t41xpXgKVrrDJiBNpY2Hq2rnaGvEfivwUPlSgwU1uDq0NEF_k24Hjado1CXdNl7_KHb3tXbHi0E46DrA_XQfgNekjMLPuDVoc7Ix-PD-_I5Wr09vSwXq8iIRHWR1Gi1KkqpNQjJVMEtA41ayAIxBjSSF9okY06LmS6U5awAXghuQaapYHJGbvd3N20zxghdXrlg0HuoselDLlmix08jvlGa7KWmbUJo0eab1lXQDjln-Y5vfuSb7_jmB76j7-bwoi8qLP9dR6DyF8Etd6g</recordid><startdate>20240523</startdate><enddate>20240523</enddate><creator>Sharma, Rahul</creator><creator>Arumugam, Neelakantan</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1287-7235</orcidid><orcidid>https://orcid.org/0000-0002-0762-8146</orcidid></search><sort><creationdate>20240523</creationdate><title>Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae</title><author>Sharma, Rahul ; Arumugam, Neelakantan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-39ef97bd399a2307b1f0a9e923bee4aec31b9c5efffe89b7f10ba1b21fa366203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Rahul</creatorcontrib><creatorcontrib>Arumugam, Neelakantan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Rahul</au><au>Arumugam, Neelakantan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae</atitle><jtitle>Natural product research</jtitle><addtitle>Nat Prod Res</addtitle><date>2024-05-23</date><risdate>2024</risdate><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>1478-6419</issn><eissn>1478-6427</eissn><abstract>Mosquito-borne diseases are a major public-health concern worldwide. The development of resistance in mosquitoes to the existing larvicides and the associated-risks necessitates the exploration of novel molecules to control vector-borne pathogens. This study demonstrates that N-alkylamides [2
,4
-N-isobutyl-undeca-2,4-diene-8,10-diynamide (
) and 2
,4
,8
,10
-N-isobutyl-dodeca-2,4,8,10-tetraenamide (
)] of
exhibit biocidal action against
and
larvae. The LC
for
and
were 44.19 and 18.28 ppm against
larvae, and 30.89 and 11.75 ppm against
larvae, respectively. We further observed that the chain length, degree of unsaturation, and terminal methylation influence the larvicidal efficacy of N-alkylamides. HPLC-assisted quantification revealed that the content of both
(19.01 mg/g) and
(68.55 mg/g) was maximum in the flowers of
. Thus, this study concludes that N-alkylamides are promising alternatives to control mosquito larvae and can be used as standard for quantitation in test samples.</abstract><cop>England</cop><pmid>38779992</pmid><doi>10.1080/14786419.2024.2357666</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1287-7235</orcidid><orcidid>https://orcid.org/0000-0002-0762-8146</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1478-6419 |
| ispartof | Natural product research, 2024-05, p.1-6 |
| issn | 1478-6419 1478-6427 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3059257108 |
| source | Taylor and Francis Science and Technology Collection |
| title | Biocidal efficacy of olefinic N-alkylamides against Aedes aegypti and Culex quinquefasciatus larvae |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T02%3A01%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biocidal%20efficacy%20of%20olefinic%20N-alkylamides%20against%20Aedes%20aegypti%20and%20Culex%20quinquefasciatus%20larvae&rft.jtitle=Natural%20product%20research&rft.au=Sharma,%20Rahul&rft.date=2024-05-23&rft.spage=1&rft.epage=6&rft.pages=1-6&rft.issn=1478-6419&rft.eissn=1478-6427&rft_id=info:doi/10.1080/14786419.2024.2357666&rft_dat=%3Cproquest_cross%3E3059257108%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c257t-39ef97bd399a2307b1f0a9e923bee4aec31b9c5efffe89b7f10ba1b21fa366203%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3059257108&rft_id=info:pmid/38779992&rfr_iscdi=true |