Crosstalk between mitotic reassembly and repair of the nuclear envelope

In eukaryotic cells, the nuclear envelope (NE) is a membrane partition between the nucleus and the cytoplasm to compartmentalize nuclear contents. It plays an important role in facilitating nuclear functions including transcription, DNA replication and repair. In mammalian cells, the NE breaks down...

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Bibliographic Details
Published in:Nucleus (Austin, Tex.) Tex.), 2024-12, Vol.15 (1), p.2352203-2352203
Main Authors: Kono, Yohei, Shimi, Takeshi
Format: Article
Language:English
Subjects:
Animals
BAF
Cell Nucleus - metabolism
DNA Repair
ESCRT-III
Humans
lamin
lamina
Mitosis
NPC
nuclear envelope
Nuclear Envelope - metabolism
nuclear envelope reassembly
nuclear envelope rupture
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Summary:In eukaryotic cells, the nuclear envelope (NE) is a membrane partition between the nucleus and the cytoplasm to compartmentalize nuclear contents. It plays an important role in facilitating nuclear functions including transcription, DNA replication and repair. In mammalian cells, the NE breaks down and then reforms during cell division, and in interphase it is restored shortly after the NE rupture induced by mechanical force. In this way, the partitioning effect is regulated through dynamic processes throughout the cell cycle. A failure in rebuilding the NE structure triggers the mixing of nuclear and cytoplasmic contents, leading to catastrophic consequences for the nuclear functions. Whereas the precise details of molecular mechanisms for NE reformation during cell division and NE restoration in interphase are still being investigated, here, we mostly focus on mammalian cells to describe key aspects that have been identified and to discuss the crosstalk between them.
ISSN:1949-1034
1949-1042
DOI:10.1080/19491034.2024.2352203