Detection of focal to bilateral tonic–clonic seizures using a connected shirt

• Published in: Epilepsia (Copenhagen) 2024-08, Vol.65 (8), p.2280-2294
• Main Authors: Gharbi, Oumayma, Lamrani, Yassine, St‐Jean, Jérôme, Jahani, Amirhossein, Toffa, Dènahin Hinnoutondji, Tran, Thi Phuoc Yen, Robert, Manon, Nguyen, Dang Khoa, Bou Assi, Elie
• Format: Article
• Language: English
• Subjects: acceleration; Algorithms; biomedical signal processing; connected shirt; Convulsions & seizures; EEG; EKG; electrocardiogram; Epilepsy; False alarms; Latency; machine learning; seizure detection; Seizures; Sensitivity analysis; wearable biosensors
• ISSN: 0013-9580; 1528-1167; 1528-1167
• DOI: 10.1111/epi.18021

Objective This study was undertaken to develop and evaluate a machine learning‐based algorithm for the detection of focal to bilateral tonic–clonic seizures (FBTCS) using a novel multimodal connected shirt. Methods We prospectively recruited patients with epilepsy admitted to our epilepsy monitoring unit and asked them to wear the connected shirt while under simultaneous video‐electroencephalographic monitoring. Electrocardiographic (ECG) and accelerometric (ACC) signals recorded with the connected shirt were used for the development of the seizure detection algorithm. First, we used a sliding window to extract linear and nonlinear features from both ECG and ACC signals. Then, we trained an extreme gradient boosting algorithm (XGBoost) to detect FBTCS according to seizure onset and offset annotated by three board‐certified epileptologists. Finally, we applied a postprocessing step to regularize the classification output. A patientwise nested cross‐validation was implemented to evaluate the performances in terms of sensitivity, false alarm rate (FAR), time in false warning (TiW), detection latency, and receiver operating characteristic area under the curve (ROC‐AUC). Results We recorded 66 FBTCS from 42 patients who wore the connected shirt for a total of 8067 continuous hours. The XGBoost algorithm reached a sensitivity of 84.8% (56/66 seizures), with a median FAR of .55/24 h and a median TiW of 10 s/alarm. ROC‐AUC was .90 (95% confidence interval = .88–.91). Median detection latency from the time of progression to the bilateral tonic–clonic phase was 25.5 s. Significance The novel connected shirt allowed accurate detection of FBTCS with a low false alarm rate in a hospital setting. Prospective studies in a residential setting with a real‐time and online seizure detection algorithm are required to validate the performance and usability of this device.