Comprehensive assessment of ocular parameters for identifying diagnostic indicators of diabetic peripheral neuropathy

Purpose To explore variations in systemic and ocular parameters among patients with diabetes, both with and without diabetic peripheral neuropathy (DPN) and to identify sensitive indicators for DPN diagnosis. Methods Ninty-five patients with type 2 diabetes mellitus (T2DM) were involved in this cros...

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Bibliographic Details
Published in:Acta diabetologica 2024-10, Vol.61 (10), p.1283-1291
Main Authors: Chen, Yesheng, Xu, Zhicong, Liang, Anyi, Chen, Ruoyu, Wang, Zicheng, Chen, Xiaojun, Zheng, Kangyan, Lu, Peiyao, Liang, Huilin, Cao, Dan, Zhang, Liang
Format: Article
Language:English
Subjects:
Adult
Aged
Albumin
Angiography
Confocal microscopy
Cornea
Cornea - diagnostic imaging
Cornea - pathology
Cross-Sectional Studies
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetic Neuropathies - blood
Diabetic Neuropathies - diagnosis
Diabetic Neuropathies - etiology
Diabetic neuropathy
Diabetic Retinopathy - blood
Diabetic Retinopathy - diagnosis
Diagnosis
Erythrocytes
Female
Glycated Hemoglobin - analysis
Glycated Hemoglobin - metabolism
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Microscopy, Confocal
Middle Aged
Nerve Fibers - pathology
Original Article
Peripheral neuropathy
Regression analysis
Retinopathy
Risk assessment
Tomography, Optical Coherence
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Summary:Purpose To explore variations in systemic and ocular parameters among patients with diabetes, both with and without diabetic peripheral neuropathy (DPN) and to identify sensitive indicators for DPN diagnosis. Methods Ninty-five patients with type 2 diabetes mellitus (T2DM) were involved in this cross-sectional study, including 49 without DPN and 46 with DPN. Ocular parameters were obtained using optical coherence tomography angiography (OCTA) and corneal confocal microscopy (CCM). Result Patients with DPN presented with significantly higher HbA1c (p 
ISSN:1432-5233
0940-5429
1432-5233
DOI:10.1007/s00592-024-02299-w