IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroi...

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Bibliographic Details
Published in:Journal of personalized medicine 2024-05, Vol.14 (5), p.488
Main Authors: Shkundin, Anton, Halaris, Angelos
Format: Article
Language:English
Subjects:
Amino acids
Angiogenesis
Blood circulation
Brain
Cell activation
Cerebrospinal fluid
Chemokines
CXC chemokines
Cytokines
Development and progression
Disease susceptibility
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Homeostasis
Hypothalamus
Immune system
Inflammation
Interleukin 8
Interleukins
Ligands
Mental disorders
Nervous system
Neurophysiology
Neuroprotection
Neutrophils
Precision medicine
Proteins
Psychoneuroimmunology
Reactive oxygen species
Tumor necrosis factor-TNF
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Summary:Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation and disease progression. Additionally, CXCL8 gene polymorphisms can alter IL-8 production, leading to potential differences in disease susceptibility, progression, and severity across populations. IL-8 levels vary among neuropsychiatric conditions, demonstrating sensitivity to psychosocial stressors and disease severity. IL-8 can be detected in blood circulation, cerebrospinal fluid (CSF), and urine, making it a promising candidate for a broad-spectrum biomarker. This review highlights the need for further research on the diverse effects of IL-8 and the associated implications for personalized medicine. A thorough understanding of its complex role could lead to the development of more effective and personalized treatment strategies for neuropsychiatric conditions.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm14050488