IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

• Published in: Journal of personalized medicine 2024-05, Vol.14 (5), p.488
• Main Authors: Shkundin, Anton, Halaris, Angelos
• Format: Article
• Language: English
• Subjects: Amino acids; Angiogenesis; Blood circulation; Brain; Cell activation; Cerebrospinal fluid; Chemokines; CXC chemokines; Cytokines; Development and progression; Disease susceptibility; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Homeostasis; Hypothalamus; Immune system; Inflammation; Interleukin 8; Interleukins; Ligands; Mental disorders; Nervous system; Neurophysiology; Neuroprotection; Neutrophils; Precision medicine; Proteins; Psychoneuroimmunology; Reactive oxygen species; Tumor necrosis factor-TNF
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm14050488

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological and psychiatric health. It exerts a profound effect on immune cell activation and brain function, suggesting potential roles in both neuroprotection and neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation and disease progression. Additionally, CXCL8 gene polymorphisms can alter IL-8 production, leading to potential differences in disease susceptibility, progression, and severity across populations. IL-8 levels vary among neuropsychiatric conditions, demonstrating sensitivity to psychosocial stressors and disease severity. IL-8 can be detected in blood circulation, cerebrospinal fluid (CSF), and urine, making it a promising candidate for a broad-spectrum biomarker. This review highlights the need for further research on the diverse effects of IL-8 and the associated implications for personalized medicine. A thorough understanding of its complex role could lead to the development of more effective and personalized treatment strategies for neuropsychiatric conditions.