Association of latent autoimmune diabetes of adults with type 3 polyglandular autoimmune syndrome-a diagnostic challenge

• Published in: Journal of the Pakistan Medical Association 2024-05, Vol.74 (5), p.990-992
• Main Authors: Rehman, Urooj Lal, Hamza, Hafiz Muhammad, Malik, Muhammad Muiz, Awan, Ayaz Ahmed
• Format: Article
• Language: English
• Subjects: Adult; Autoimmune diseases; Case studies; Diabetes; Diagnosis; Humans; Latent Autoimmune Diabetes in Adults - diagnosis; Male; Polyendocrinopathies, Autoimmune - complications; Polyendocrinopathies, Autoimmune - diagnosis; Polyendocrinopathies, Autoimmune - drug therapy; Risk factors; Thyroid diseases
• ISSN: 0030-9982; 0030-9982
• DOI: 10.47391/JPMA.10108

Autoimmune polyendocrine syndromes (APS) encompass m ultiple e ndocrin e gland ins ufficiencies asso ci ated wit h auto immune disease. This c as e report underscores the importance of recognising the association between latent auto immune di a betes of ad ults (LADA) and type 3 polyglandular syndrome. A 42-year-old man belonging to R awalpi ndi, Pakistan, p resented to th e out patient department (OPD) of Ali Medi cal Centre, Islamab ad, i n Januar y 2023 with the complaints o f e xtreme thirs t and frequent urination. The patient reported consistently raised app etite an d eating four to five meals a day along with abrupt weight loss, dry mouth, fatigue occasional dizziness, an d dyspnoea. He was diagno s ed with type 3 polygla ndular syndrome w ith associat io n of LADA. Daily administration of 10 units of glargine insulin, along with six units of rapid-acting insulin, was prescribed. The patient's H bA1c level reduce d in a few months afte r succe ssive follow-up. Patients who exhi bit uncontrol led diabe tes despite dietar y and oral hypoglycaemic management should be further investigated for multiple au toimmune endocrine disorders.