Triglyceride-Glucose Index Associated with Future Renal Function Decline in the General Population

The triglyceride-glucose index (TyG index), calculated as the logarithmic product of fasting triglyceride and glucose concentrations, is recognized as a simple marker of insulin resistance. However, the association between the TyG index and future decline of renal function remains unclear in the gen...

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Bibliographic Details
Published in:Journal of general internal medicine : JGIM 2024-12, Vol.39 (16), p.3225-3233
Main Authors: Yoshida, Daisuke, Ikeda, Shota, Shinohara, Keisuke, Kazurayama, Masaya, Tanaka, Shinji, Yamaizumi, Masamitsu, Nagayoshi, Hirokazu, Toyama, Kensuke, Kinugawa, Shintaro
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Blood Glucose - analysis
Body mass index
Body size
Chronic illnesses
Cohort Studies
Diabetes mellitus
Disease Progression
Disease resistance
Dyslipidemia
Epidermal growth factor receptors
Fasting
Female
Glomerular filtration rate
Glomerular Filtration Rate - physiology
Glucose
Glycemic index
Health risks
Humans
Hypertension
Insulin resistance
Insulin Resistance - physiology
Kidney - physiology
Kidney - physiopathology
Kidney diseases
Longitudinal Studies
Male
Medical diagnosis
Middle Aged
Observational studies
Population decline
Population studies
Quartiles
Renal function
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Retrospective Studies
Risk Factors
Statistical models
Subgroups
Triglycerides
Triglycerides - blood
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Summary:The triglyceride-glucose index (TyG index), calculated as the logarithmic product of fasting triglyceride and glucose concentrations, is recognized as a simple marker of insulin resistance. However, the association between the TyG index and future decline of renal function remains unclear in the general population. To investigate whether the TyG index was associated with future decline of renal function in the general population who had not progressed to chronic kidney disease stage G2. Retrospective longitudinal observational cohort study. Individuals who received a population-based health checkup at JA Ehime Kouseiren Checkup Center from 2010 to 2019 (n = 134,007). Individuals without data of baseline fasting triglyceride or glucose levels, or baseline and follow-up data of estimated glomerular filtration rate (eGFR), or those with baseline eGFR 
ISSN:0884-8734
1525-1497
1525-1497
DOI:10.1007/s11606-024-08809-4