Anti-inflammatory and antinociceptive effects, toxicity, and phytochemical analysis of Beaumontia grandiflora Wall

Preliminary pharmacological studies revealed that the EtOAc fraction (BGEA) might be the main active fraction with anti-inflammatory and antinociceptive effects in Wall. Further assays on BGEA at doses of 200, 400, and 800 mg/kg using four animal models showed that it could inhibit the xylene-induce...

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Published in:Natural product research 2024-05, p.1-7
Main Authors: Yang, Rui, Teng, Dan, Yang, Ming-Rui, Li, Yi-Huan, Xiao, Jian-Fen, Zhang, Qian-Ru, He, Hong-Ping, Jiang, Hua-Yi
Format: Article
Language:English
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Summary:Preliminary pharmacological studies revealed that the EtOAc fraction (BGEA) might be the main active fraction with anti-inflammatory and antinociceptive effects in Wall. Further assays on BGEA at doses of 200, 400, and 800 mg/kg using four animal models showed that it could inhibit the xylene-induced ear edema, carrageenan-induced paw edema, and acetic acid-induced writhing and prolong the latency time in the hot-plate test. ELISA analysis revealed that the anti-inflammatory activity of BGEA might be associated with the decrease of TNF- , IL-1 , and IL-6 levels and the increase of the IL-10 level. The acute toxicity test showed that except for the -BuOH fraction, the LD values of the extract and other three fractions were higher than 2000 mg/kg bw. Finally, 14 compounds were identified from BGEA by LC-MS. This research provides some basis for the folk use of in the treatment of inflammation and pain-related diseases.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2024.2358386