Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis

• Published in: Pediatric and developmental pathology 2024-07, Vol.27 (4), p.327-334
• Main Authors: Lopez-Nunez, Oscar, Bernieh, Anas, Kliewer, Kara L., Kemtur, Pratibha, Bolton, Scott M., Mukkada, Vincent A., Schablein, Ryan, Woods, Christopher, Rothenberg, Marc E., Collins, Margaret H.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biopsy; Child; Child, Preschool; Eosinophilic Esophagitis - diagnosis; Eosinophilic Esophagitis - pathology; Esophagoscopy; Esophagus - pathology; Female; Humans; Male; Retrospective Studies
• ISSN: 1093-5266; 1615-5742; 1615-5742
• DOI: 10.1177/10935266241255723

Background: Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS). Methods: The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. P ≤ .05 was considered significant. Results: Median age (P = .82) or height (P = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm2) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), P