3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration

There is an essential clinical need to develop rapid process scaffolds to repair bone defects. The current research presented the development of calcium zirconium silicate/polycaprolactone for bone tissue engineering utilising melt extrusion-based 3D printing. Calcium zirconium silicate (CZS) nanopa...

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Bibliographic Details
Published in:Polymers 2024-05, Vol.16 (10), p.1389
Main Authors: Emadi, Hosein, Baghani, Mostafa, Masoudi Rad, Maryam, Hoomehr, Bahareh, Baniassadi, Majid, Lotfian, Saeid
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Additive manufacturing
Analysis
Apatite
Bioceramics
Biocompatibility
Biological activity
Biological properties
Bones
Calcium compounds
Calcium zirconate
Composite materials
Compressive strength
Crystal defects
Crystallization
Identification and classification
Mechanical properties
Melting points
Nanoparticles
Nitrates
Polycaprolactone
Polymers
Printing
Radiation
Regeneration (physiology)
Scaffolds
Silicates
Thermal degradation
Three dimensional composites
Tissue engineering
Zirconium
Zirconium silicate
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Summary:There is an essential clinical need to develop rapid process scaffolds to repair bone defects. The current research presented the development of calcium zirconium silicate/polycaprolactone for bone tissue engineering utilising melt extrusion-based 3D printing. Calcium zirconium silicate (CZS) nanoparticles were added to polycaprolactone (PCL) porous scaffolds to enhance their biological and mechanical properties, while the resulting properties were studied extensively. No significant difference was found in the melting point of the samples, while the crystallisation temperature points of the samples containing bioceramic increased from 36.1 to 40.2 °C. Thermal degradation commenced around 350 °C for all materials. According to our results, increasing the CZS content from 0 to 40 wt.% (PC40) in porous scaffolds (porosity about 55-62%) improved the compressive strength from 2.8 to 10.9 MPa. Furthermore, apatite formation ability in SBF solution increased significantly by enhancing the CZS percentage. According to MTT test results, the viability of MG63 cells improved remarkably (~29%) in PC40 compared to pure PCL. These findings suggest that a 3D-printed PCL/CZS composite scaffold can be fabricated successfully and shows great potential as an implantable material for bone tissue engineering applications.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym16101389