Synthesis and study of organo‐modified silica based hydrogels: Rheological properties and drug release kinetics

The method of synthesis of unmodified and organo‐modified silica hydrogels and their composites with orotic acid as a model drug was developed. The hydrogels had a pH of 6.5–7.8. The particulate nature and highly porous structures of the hydrogel materials were revealed using scanning electron and o...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2024-06, Vol.112 (6), p.e35418-n/a
Main Authors: Parfenyuk, Elena V., Dolinina, Ekaterina S., Kraev, Anton S.
Format: Article
Language:English
Subjects:
Catalysts
Chemical synthesis
Controlled release
Delayed-Action Preparations - chemistry
Delayed-Action Preparations - pharmacokinetics
Drug Liberation
Hydrogels
Hydrogels - chemistry
Kinetics
Light microscopy
Optical microscopy
organically modified silica hydrogels
Orotic acid
Pseudoplasticity
release kinetics
Rheological properties
Rheology
Silica
silica hydrogel
Silicon dioxide
Silicon Dioxide - chemistry
sol–gel
Thixotropy
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Summary:The method of synthesis of unmodified and organo‐modified silica hydrogels and their composites with orotic acid as a model drug was developed. The hydrogels had a pH of 6.5–7.8. The particulate nature and highly porous structures of the hydrogel materials were revealed using scanning electron and optical microscopy methods. The content of aqueous phase in the hydrogels was 99% or more. In order to evaluate the possibility of their application as a basis for development of novel soft drug formulations and cosmetic compositions, rheological properties of the hydrogels and in vitro release kinetics of the drug were studied. The effects of synthesis conditions (increasing concentration of catalyst of silica sol formation, drug loading) and the silica matrix modification with various organic groups on the indicated properties were investigated. It was found that all synthesized hydrogels exhibited pseudoplasticity, thixotropy and controlled release of the drug, which are important for their potential application. However, in general, the indicated effects led to worsening the properties of the hydrogel materials in comparison with the unmodified silica hydrogels.
ISSN:1552-4973
1552-4981
1552-4981
DOI:10.1002/jbm.b.35418