Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

• Published in: CNS neuroscience & therapeutics 2024-05, Vol.30 (5), p.e14763-n/a
• Main Authors: Hussain, Md Sadique, Moglad, Ehssan, Afzal, Muhammad, Sharma, Shilpa, Gupta, Gaurav, Sivaprasad, G. V., Deorari, Mahamedha, Almalki, Waleed Hassan, Kazmi, Imran, Alzarea, Sami I., Shahwan, Moyad, Pant, Kumud, Ali, Haider, Singh, Sachin Kumar, Dua, Kamal, Subramaniyan, Vetriselvan
• Format: Article
• Language: English
• Subjects: Animals; Autophagy; Autophagy - genetics; Autophagy - physiology; Biosynthesis; Brain research; Disease; Dopamine; Dopamine receptors; Genomics; Humans; Illnesses; Inflammation; Medical innovations; MicroRNAs; Mitochondria; Movement disorders; ncRNA; Neurodegenerative diseases; neuroinflammation; Non-coding RNA; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Pathophysiology; Proteins; RNA, Untranslated - genetics; Substantia nigra; Synuclein; α‐synuclein
• ISSN: 1755-5930; 1755-5949
• DOI: 10.1111/cns.14763

Background Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy—a crucial cellular process for maintaining protein and organelle integrity. Methods This review focuses on the role of non‐coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology. Special attention was given to the examination of ncRNAs' regulatory impacts in various PD models and patient samples. Results Findings reveal that ncRNAs are pivotal in regulating key processes associated with PD progression, including autophagy, α‐synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. Dysregulation of specific ncRNAs appears to be closely linked to these pathogenic processes. Conclusion ncRNAs hold significant therapeutic potential for addressing autophagy‐related mechanisms in PD. The review highlights innovative therapeutic strategies targeting autophagy‐related ncRNAs and discusses the challenges and prospective directions for developing ncRNA‐based therapies in clinical practice. The insights from this study underline the importance of ncRNAs in the molecular landscape of PD and their potential in novel treatment approaches. Parkinson's disease (PD) progression is linked to the disruption of autophagy, a cellular process essential for maintaining protein and organelle health. Recent studies reveal that non‐coding RNAs (ncRNAs) are crucial in regulating autophagy, offering new insights into the molecular dynamics of PD. These ncRNAs are implicated in key pathological processes of PD, including autophagy regulation, α‐synuclein aggregation, mitochondrial dysfunction, and neuroinflammation.