Development of ophthalmic nanoemulsions of β-caryophyllene for the treatment of Acanthamoeba keratitis

[Display omitted] Although rare, amoebic keratitis (AK) is a disease caused by Acanthamoeba spp. that can lead to blindness. The drugs currently available for its treatment are very toxic, which has motivated the investigation for more effective and safe therapeutic options. In this study, the in vi...

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Bibliographic Details
Published in:International journal of pharmaceutics 2024-06, Vol.659, p.124252, Article 124252
Main Authors: Santos Porto, Douglas, da Costa Bernardo Port, Bianca, Conte, Júlia, Fretes Argenta, Debora, Pereira Balleste, Maira, Amadeu Micke, Gustavo, Machado Campos, Ângela, Silva Caumo, Karin, Caon, Thiago
Format: Article
Language:English
Subjects:
Acanthamoeba keratitis
Nanoemulsions
β-caryophyllene
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Summary:[Display omitted] Although rare, amoebic keratitis (AK) is a disease caused by Acanthamoeba spp. that can lead to blindness. The drugs currently available for its treatment are very toxic, which has motivated the investigation for more effective and safe therapeutic options. In this study, the in vitro activity of ß-caryophyllene (BCP) was exploited taking into account its action against other protozoans as well as its well-known healing and anti-inflammatory properties (aspects relevant for the AK pathogenesis). On the other hand, high volatilization and oxidation phenomena are found for this compound, which led to its incorporation into nanoemulsions (NEs). Two emulsifying agents were tested, resulting in monodisperse systems with reduced droplet size (
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2024.124252