Targeting the Wnt/β-catenin cascade in osteosarcoma: The potential of ncRNAs as biomarkers and therapeutics

• Published in: Pathology, research and practice research and practice, 2024-07, Vol.259, p.155346, Article 155346
• Main Authors: Fuloria, Shivkanya, Yadav, Geeta, Menon, Soumya V., Ali, Haider, Pant, Kumud, Kaur, Mandeep, Deorari, Mahamedha, Sekar, Mahendran, Narain, Kamal, Kumar, Sokindra, Fuloria, Neeraj Kumar
• Format: Article
• Language: English
• Subjects: beta Catenin - genetics; beta Catenin - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Bone Neoplasms - drug therapy; Bone Neoplasms - genetics; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; CircRNAs; Gene Expression Regulation, Neoplastic; Humans; LncRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; MiRNAs; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - genetics; Osteosarcoma - metabolism; Osteosarcoma - pathology; RNA, Circular - genetics; RNA, Circular - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Untranslated - genetics; RNA, Untranslated - metabolism; Wnt Signaling Pathway - genetics; Wnt/β-catenin
• ISSN: 0344-0338; 1618-0631; 1618-0631
• DOI: 10.1016/j.prp.2024.155346

Osteosarcoma (OS) is a bone cancer which stems from several sources and presents with diverse clinical features, making evaluation and treatment difficult. Chemotherapy tolerance and restricted treatment regimens hinder progress in survival rates, requiring new and creative therapeutic strategies. The Wnt/β-catenin system has been recognised as an essential driver of OS development, providing potential avenues for therapy. Non-coding RNAs (ncRNAs), such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs), are essential in modulating the Wnt/β-catenin cascade in OS. MiRNAs control the system by targeting vital elements, while lncRNAs and circRNAs interact with system genes, impacting OS growth and advancement. This paper thoroughly analyses the intricate interplay between ncRNAs and the Wnt/β-catenin cascade in OS. We examine how uncontrolled levels of miRNAs, lncRNAs, and circRNAs lead to an abnormal Wnt/β-catenin network, which elevates the development, spread, and susceptibility to the treatment of OS. We emphasise the potential of ncRNAs as diagnostic indicators and avenues for treatment in OS care. The review offers valuable insights for academics and clinicians studying OS aetiology and creating new treatment techniques for the ncRNA-Wnt/β-catenin cascade. Utilising the oversight roles of ncRNAs in the Wnt/β-catenin system shows potential for enhancing the outcomes of patients and progressing precision medicine in OS therapy.