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Which factors influence Demodex mite density in standardized superficial skin biopsy in patients with rosacea? A prospective cross-sectional analysis
Rosacea is a chronic cutaneous disease that manifests with facial erythema, telangiectasia, papules and pustules on the central face. Although the pathogenesis is not well established, rosacea appears to have a close relationship with Demodex mites. The aim of the study was to elucidate the factors...
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| Published in: | Archives of dermatological research 2024-05, Vol.316 (6), p.231, Article 231 |
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| creator | Ozdemir Cetinkaya, Pinar Özkesici Kurt, Birgül Altunay, Ilknur Kivanc Aksu Cerman, Asli |
| description | Rosacea is a chronic cutaneous disease that manifests with facial erythema, telangiectasia, papules and pustules on the central face. Although the pathogenesis is not well established, rosacea appears to have a close relationship with
Demodex
mites. The aim of the study was to elucidate the factors influencing
Demodex
mite density by standardized superficial skin biopsy (SSSB) in patients with rosacea. This prospective, cross-sectional study included 200 patients with rosacea. Clinical characteristics of the patients were recorded and SSSB was used to measure
Demodex
density (Dd). If Dd was |
| doi_str_mv | 10.1007/s00403-024-03049-2 |
| format | article |
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Demodex
mites. The aim of the study was to elucidate the factors influencing
Demodex
mite density by standardized superficial skin biopsy (SSSB) in patients with rosacea. This prospective, cross-sectional study included 200 patients with rosacea. Clinical characteristics of the patients were recorded and SSSB was used to measure
Demodex
density (Dd). If Dd was < 5
D
/cm
2
in the first SSSB, SSSB was repeated 4 more times to avoid false negative results. Of 200 patients, 152 (76%) were females and 48 (24%) males with a mean age of 43.47 ± 11.87 years. Ninety-nine patients (49.5%) had erythematotelangiectatic (ETR) and 101 patients (50.5%) had papulopustular (PPR) subtype of rosacea. Among 200 patients, the ratio of cumulative positive results of the consecutive SSSBs were as follows: 1st SSSB = 125 (62.5%), 2nd SSSB = 155 (77.5%), 3rd SSSB = 170 (85%), 4th SSSB = 173 (86.5%) and 5th SSSB = 174 (87%). The ratio of detecting
Demodex
infestation in the first SSSB was significantly lower in patients with PPR (55/101, 54.5%) than in patients with ETR (70/99, 70.7%). Median total
Demodex
mite density and
D. folliculorum
density were significantly higher in the ETR group than in the PPR group. There was a statistically significant relationship between density of
Demodex
tails in dermoscopy and positive/negative results of
Demodex
infestation in SSSB. As a conclusion,
Demodex
mite density by SSSB was influenced by various factors such as subtypes of rosacea, types of
Demodex
species, and dermoscopic findings.</description><identifier>ISSN: 1432-069X</identifier><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-024-03049-2</identifier><identifier>PMID: 38787449</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Animals ; Biopsy ; Cross-Sectional Studies ; Demodex ; Dermatology ; Erythema ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mite Infestations - diagnosis ; Mite Infestations - pathology ; Mites ; Original Paper ; Prospective Studies ; Rosacea ; Rosacea - diagnosis ; Rosacea - parasitology ; Rosacea - pathology ; Skin - parasitology ; Skin - pathology ; Skin diseases ; Statistical analysis</subject><ispartof>Archives of dermatological research, 2024-05, Vol.316 (6), p.231, Article 231</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-aab996812ac1e188b98694e80e19a1bc288969e42cb500857a176dc9fb51b6743</cites><orcidid>0000-0003-3979-7486 ; 0000-0003-3121-5816 ; 0000-0002-1354-7123 ; 0000-0001-5286-3260</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38787449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozdemir Cetinkaya, Pinar</creatorcontrib><creatorcontrib>Özkesici Kurt, Birgül</creatorcontrib><creatorcontrib>Altunay, Ilknur Kivanc</creatorcontrib><creatorcontrib>Aksu Cerman, Asli</creatorcontrib><title>Which factors influence Demodex mite density in standardized superficial skin biopsy in patients with rosacea? A prospective cross-sectional analysis</title><title>Archives of dermatological research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Rosacea is a chronic cutaneous disease that manifests with facial erythema, telangiectasia, papules and pustules on the central face. Although the pathogenesis is not well established, rosacea appears to have a close relationship with
Demodex
mites. The aim of the study was to elucidate the factors influencing
Demodex
mite density by standardized superficial skin biopsy (SSSB) in patients with rosacea. This prospective, cross-sectional study included 200 patients with rosacea. Clinical characteristics of the patients were recorded and SSSB was used to measure
Demodex
density (Dd). If Dd was < 5
D
/cm
2
in the first SSSB, SSSB was repeated 4 more times to avoid false negative results. Of 200 patients, 152 (76%) were females and 48 (24%) males with a mean age of 43.47 ± 11.87 years. Ninety-nine patients (49.5%) had erythematotelangiectatic (ETR) and 101 patients (50.5%) had papulopustular (PPR) subtype of rosacea. Among 200 patients, the ratio of cumulative positive results of the consecutive SSSBs were as follows: 1st SSSB = 125 (62.5%), 2nd SSSB = 155 (77.5%), 3rd SSSB = 170 (85%), 4th SSSB = 173 (86.5%) and 5th SSSB = 174 (87%). The ratio of detecting
Demodex
infestation in the first SSSB was significantly lower in patients with PPR (55/101, 54.5%) than in patients with ETR (70/99, 70.7%). Median total
Demodex
mite density and
D. folliculorum
density were significantly higher in the ETR group than in the PPR group. There was a statistically significant relationship between density of
Demodex
tails in dermoscopy and positive/negative results of
Demodex
infestation in SSSB. As a conclusion,
Demodex
mite density by SSSB was influenced by various factors such as subtypes of rosacea, types of
Demodex
species, and dermoscopic findings.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Biopsy</subject><subject>Cross-Sectional Studies</subject><subject>Demodex</subject><subject>Dermatology</subject><subject>Erythema</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mite Infestations - diagnosis</subject><subject>Mite Infestations - pathology</subject><subject>Mites</subject><subject>Original Paper</subject><subject>Prospective Studies</subject><subject>Rosacea</subject><subject>Rosacea - diagnosis</subject><subject>Rosacea - parasitology</subject><subject>Rosacea - pathology</subject><subject>Skin - parasitology</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Statistical analysis</subject><issn>1432-069X</issn><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcuOFSEQhonROOPoC7gwJG7ctBbQp4GVmYzXZBI3Gt0Rmq72MPZNilaP7-H7yjlnvMSFGyjyf_VXkZ-x-wIeCwD9hABqUBXIugIFta3kDXYqaiUraOyHm3_VJ-wO0RWUJm3EbXaijDa6ru0p-_F-G8OW9z7kORGPUz-sOAXkz3CcO_zGx5iRdzhRzLsic8p-6nzq4nfsOK0Lpj6G6AdOn4raxnmhA7f4HHHKxL_GvOVpJh_QP-XnfCn1giHHL8hDqami_Wueiocvx44i3WW3ej8Q3ru-z9i7F8_fXryqLt-8fH1xflkFJZtced9a2xghfRAojGmtaWyNBlBYL9ogjbGNxVqGdgNgNtoL3XTB9u1GtI2u1Rl7dPQtS31ekbIbIwUcBj_hvJJT0IAyG1B79OE_6NW8prLvntJSa2msKpQ8UoefJezdkuLo084JcPvQ3DE0V0Jzh9CcLE0Prq3XdsTud8uvlAqgjgAVafqI6c_s_9j-BNjlpMg</recordid><startdate>20240524</startdate><enddate>20240524</enddate><creator>Ozdemir Cetinkaya, Pinar</creator><creator>Özkesici Kurt, Birgül</creator><creator>Altunay, Ilknur Kivanc</creator><creator>Aksu Cerman, Asli</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3979-7486</orcidid><orcidid>https://orcid.org/0000-0003-3121-5816</orcidid><orcidid>https://orcid.org/0000-0002-1354-7123</orcidid><orcidid>https://orcid.org/0000-0001-5286-3260</orcidid></search><sort><creationdate>20240524</creationdate><title>Which factors influence Demodex mite density in standardized superficial skin biopsy in patients with rosacea? A prospective cross-sectional analysis</title><author>Ozdemir Cetinkaya, Pinar ; Özkesici Kurt, Birgül ; Altunay, Ilknur Kivanc ; Aksu Cerman, Asli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-aab996812ac1e188b98694e80e19a1bc288969e42cb500857a176dc9fb51b6743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Biopsy</topic><topic>Cross-Sectional Studies</topic><topic>Demodex</topic><topic>Dermatology</topic><topic>Erythema</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mite Infestations - diagnosis</topic><topic>Mite Infestations - pathology</topic><topic>Mites</topic><topic>Original Paper</topic><topic>Prospective Studies</topic><topic>Rosacea</topic><topic>Rosacea - diagnosis</topic><topic>Rosacea - parasitology</topic><topic>Rosacea - pathology</topic><topic>Skin - parasitology</topic><topic>Skin - pathology</topic><topic>Skin diseases</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozdemir Cetinkaya, Pinar</creatorcontrib><creatorcontrib>Özkesici Kurt, Birgül</creatorcontrib><creatorcontrib>Altunay, Ilknur Kivanc</creatorcontrib><creatorcontrib>Aksu Cerman, Asli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozdemir Cetinkaya, Pinar</au><au>Özkesici Kurt, Birgül</au><au>Altunay, Ilknur Kivanc</au><au>Aksu Cerman, Asli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Which factors influence Demodex mite density in standardized superficial skin biopsy in patients with rosacea? A prospective cross-sectional analysis</atitle><jtitle>Archives of dermatological research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2024-05-24</date><risdate>2024</risdate><volume>316</volume><issue>6</issue><spage>231</spage><pages>231-</pages><artnum>231</artnum><issn>1432-069X</issn><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Rosacea is a chronic cutaneous disease that manifests with facial erythema, telangiectasia, papules and pustules on the central face. Although the pathogenesis is not well established, rosacea appears to have a close relationship with
Demodex
mites. The aim of the study was to elucidate the factors influencing
Demodex
mite density by standardized superficial skin biopsy (SSSB) in patients with rosacea. This prospective, cross-sectional study included 200 patients with rosacea. Clinical characteristics of the patients were recorded and SSSB was used to measure
Demodex
density (Dd). If Dd was < 5
D
/cm
2
in the first SSSB, SSSB was repeated 4 more times to avoid false negative results. Of 200 patients, 152 (76%) were females and 48 (24%) males with a mean age of 43.47 ± 11.87 years. Ninety-nine patients (49.5%) had erythematotelangiectatic (ETR) and 101 patients (50.5%) had papulopustular (PPR) subtype of rosacea. Among 200 patients, the ratio of cumulative positive results of the consecutive SSSBs were as follows: 1st SSSB = 125 (62.5%), 2nd SSSB = 155 (77.5%), 3rd SSSB = 170 (85%), 4th SSSB = 173 (86.5%) and 5th SSSB = 174 (87%). The ratio of detecting
Demodex
infestation in the first SSSB was significantly lower in patients with PPR (55/101, 54.5%) than in patients with ETR (70/99, 70.7%). Median total
Demodex
mite density and
D. folliculorum
density were significantly higher in the ETR group than in the PPR group. There was a statistically significant relationship between density of
Demodex
tails in dermoscopy and positive/negative results of
Demodex
infestation in SSSB. As a conclusion,
Demodex
mite density by SSSB was influenced by various factors such as subtypes of rosacea, types of
Demodex
species, and dermoscopic findings.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38787449</pmid><doi>10.1007/s00403-024-03049-2</doi><orcidid>https://orcid.org/0000-0003-3979-7486</orcidid><orcidid>https://orcid.org/0000-0003-3121-5816</orcidid><orcidid>https://orcid.org/0000-0002-1354-7123</orcidid><orcidid>https://orcid.org/0000-0001-5286-3260</orcidid></addata></record> |
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| issn | 1432-069X 0340-3696 1432-069X |
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| source | Springer Nature |
| subjects | Adult Aged Animals Biopsy Cross-Sectional Studies Demodex Dermatology Erythema Female Humans Male Medicine Medicine & Public Health Middle Aged Mite Infestations - diagnosis Mite Infestations - pathology Mites Original Paper Prospective Studies Rosacea Rosacea - diagnosis Rosacea - parasitology Rosacea - pathology Skin - parasitology Skin - pathology Skin diseases Statistical analysis |
| title | Which factors influence Demodex mite density in standardized superficial skin biopsy in patients with rosacea? A prospective cross-sectional analysis |
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