Intrapartum antibiotic use is associated with higher child body mass index (BMI) z-score at 4 years of age

Early life antibiotic exposure may increase obesity risk. We investigated if prenatal, intrapartum, or childhood antibiotic use is associated with child zBMI score at 4 yrs of age. We included data from the Alberta Pregnancy Outcomes and Nutrition (APrON) study, a prospective cohort study, on matern...

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Bibliographic Details
Published in:Obesity research & clinical practice 2024-05, Vol.18 (3), p.222-225
Main Authors: Cho, Nicole A., Giesbrecht, Gerald F., Dewey, Deborah, Reimer, Raylene A.
Format: Article
Language:English
Subjects:
Antibiotics
APrON
BMI z-score
Children
Obesity
Pregnancy
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Summary:Early life antibiotic exposure may increase obesity risk. We investigated if prenatal, intrapartum, or childhood antibiotic use is associated with child zBMI score at 4 yrs of age. We included data from the Alberta Pregnancy Outcomes and Nutrition (APrON) study, a prospective cohort study, on maternal and child antibiotic exposure and clinic measures of height and weight at age 4 (n = 408). Prenatal and childhood antibiotic exposure was not associated with zBMI score. Maternal intrapartum antibiotic exposure was associated with a zBMI score increase of 0.12 (95 % CI; 0.04, 0.46) in children at 4 years of age compared to non-exposure intrapartum.
ISSN:1871-403X
1878-0318
DOI:10.1016/j.orcp.2024.05.002