Elevated senescence-associated secretory phenotype index in late-life bipolar disorder

The senescence-associated secretory phenotype (SASP) is a biomarker index based on the profile of 22 blood proteins associated with cellular senescence. The SASP index has not been assessed in older patients with bipolar disorder (BD). We hypothesized that older adults with BD will have elevated cel...

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Bibliographic Details
Published in:Journal of affective disorders 2024-09, Vol.360, p.163-168
Main Authors: Tessema, Tselot, Diniz, Breno S., Vieira, Erica M., Mendes-Silva, Ana Paula, Voineskos, Aristotle N., Gildengers, Ariel G., Husain, M. Ishrat, Ortiz, Abigail, Blumberger, Daniel M., Rajji, Tarek K., Mulsant, Benoit H.
Format: Article
Language:English
Subjects:
Aging
Biomarker
Bipolar disorder
Senescence-associated secretory phenotype (SASP) index
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Summary:The senescence-associated secretory phenotype (SASP) is a biomarker index based on the profile of 22 blood proteins associated with cellular senescence. The SASP index has not been assessed in older patients with bipolar disorder (BD). We hypothesized that older adults with BD will have elevated cellular senescence burden as measured by the SASP index. We measured the 22 SASP proteins to calculate the SASP index in 38 older patients with BD and 34 non-psychiatric comparison individuals (HC). The SASP index scores were significantly higher in BD than HC after controlling for age, sex, psychopathology, and physical health (F(1,8) = 5.37, p = 0.024, η2 = 0.08). SASP index scores were also associated with higher age, more severe depressive symptoms, and physical illness burden (p 
ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2024.05.071