High‐intensity interval training mitigates the progression of periodontitis and improves behavioural aspects in rats

Aim To investigate the effects of high‐intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes. Materials and Methods Forty‐eight Wistar rats were divided into four groups: non‐trained (NT); non‐trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involvi...

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Published in:Journal of clinical periodontology 2024-09, Vol.51 (9), p.1222-1235
Main Authors: Pereira, Ramona Ramalho de Souza, Castro, Giselle Bicalho de, Magalhães, Caíque Olegário Diniz e, Costa, Karine Beatriz, Garcia, Bruna Caroline Chaves, Silva, Gabriela, Carvalho, Jaqueline do Carmo Lima, Machado, Alan Rodrigues Teixeira, Vieira, Etel Rocha, Cassilhas, Ricardo Cardoso, Pereira, Luciano José, Dias‐Peixoto, Marco Fabrício, Andrade, Eric Francelino
Format: Article
Language:English
Subjects:
Alveolar bone
Amygdala
Amygdala - metabolism
Animals
Anxiety
Behavior, Animal
Bone composition
Clinical outcomes
cognition
Disease Progression
Euthanasia
Gum disease
High-Intensity Interval Training - methods
Hippocampus
Hippocampus - metabolism
Inflammation
Interval training
Laboratory animals
Male
Oxidative Stress
Periodontics
Periodontitis
Periodontitis - therapy
Physical Conditioning, Animal
Rats
Rats, Wistar
Rodents
systemic inflammation
Thiobarbituric acid
Tumor necrosis factor
Tumor necrosis factor-TNF
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Summary:Aim To investigate the effects of high‐intensity interval training (HIIT) on periodontitis (PD) progression and behavioural outcomes. Materials and Methods Forty‐eight Wistar rats were divided into four groups: non‐trained (NT); non‐trained with PD; HIIT with PD; and HIIT. The HIIT protocol, involving daily treadmill sessions, spanned 8 weeks, with PD induced by ligature after the 6th week. Behavioural tests were conducted to assess anxiety and memory. Post euthanasia, we evaluated the systemic inflammatory profile and oxidative stress markers in the hippocampus and amygdala. A morphological evaluation and elemental composition analysis of the mandibular alveolar bone were performed. Results PD exacerbated alveolar bone level, bone surface damage and alterations in calcium and phosphorus percentages on the bone surface (p 
ISSN:0303-6979
1600-051X
1600-051X
DOI:10.1111/jcpe.14020