Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis

Meiosis is a critical step for spermatogenesis and oogenesis. Meiosis commences with pre-meiotic S phase that is subsequently followed by meiotic prophase. The meiotic prophase is characterized by the meiosis-specific chromosomal events such as chromosome recombination and homolog synapsis. Meiosis...

Full description

Saved in:
Bibliographic Details
Published in:Molecular aspects of medicine 2024-06, Vol.97, p.101282, Article 101282
Main Author: Ishiguro, Kei-ichiro
Format: Article
Language:English
Subjects:
Animals
Cell cycle
Chromosome
Gene expression
Humans
Male
Meiosis
Meiosis - genetics
Meiotic Prophase I
Prophase
Spermatogenesis
Spermatogenesis - genetics
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Meiosis is a critical step for spermatogenesis and oogenesis. Meiosis commences with pre-meiotic S phase that is subsequently followed by meiotic prophase. The meiotic prophase is characterized by the meiosis-specific chromosomal events such as chromosome recombination and homolog synapsis. Meiosis initiator (MEIOSIN) and stimulated by retinoic acid gene 8 (STRA8) initiate meiosis by activating the meiotic genes by installing the meiotic prophase program at pre-meiotic S phase. This review highlights the mechanisms of meiotic initiation and meiotic prophase progression from the point of the gene expression program and its relevance to infertility. Furthermore, upstream pathways that regulate meiotic initiation will be discussed in the context of spermatogenic development, indicating the sexual differences in the mode of meiotic entry.
ISSN:0098-2997
1872-9452
1872-9452
DOI:10.1016/j.mam.2024.101282