Reflections on the complex mechanisms of endometriosis from the perspective of ferroptosis

Ferroptosis is a novel type of iron-dependent programmed cell death characterised by intracellular iron overload, increased lipid peroxidation and abnormal accumulation of reactive oxygen species.It has been implicated in the progression of several diseases including cancer, ischaemia-reperfusion in...

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Published in:Pathology, research and practice research and practice, 2024-07, Vol.259, p.155353, Article 155353
Main Authors: Duan, Yu-han, Wang, He-lin, Liu, Meng-na, Xu, Tian-min, Zhang, Kun
Format: Article
Language:English
Subjects:
Animals
Autophagy - physiology
Endometriosis
Endometriosis - metabolism
Endometriosis - pathology
Epithelial-Mesenchymal Transition - physiology
Female
Ferroptosis
Ferroptosis - physiology
Humans
Iron - metabolism
Lipid Metabolism - physiology
Lipid peroxidation
Lipid Peroxidation - physiology
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
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Summary:Ferroptosis is a novel type of iron-dependent programmed cell death characterised by intracellular iron overload, increased lipid peroxidation and abnormal accumulation of reactive oxygen species.It has been implicated in the progression of several diseases including cancer, ischaemia-reperfusion injury, neurodegenerative diseases and liver disease. The etiology of endometriosis (EMS) is still unclear and is associated with multiple factors, often accompanied by various forms of cell death and a complex microenvironment. In recent decades, the role of non-traditional forms of cell death, represented by ferroptosis, in endometriosis has come to the attention of researchers. This article reviews the transitional role of iron homeostasis in the development of ferroptosis, the characteristics and regulatory mechanisms of ferroptosis, and focuses on summarising the links between iron death and various pathogenic mechanisms of EMS, including oxidative stress, dysregulation of lipid metabolism, inflammation, autophagy and epithelial-mesenchymal transition. The possible applications of ferroptosis in the treatment of EMS, future research directions and current issues are discussed with the aim of providing new ideas for further understanding of EMS.
ISSN:0344-0338
1618-0631
1618-0631
DOI:10.1016/j.prp.2024.155353