A case of pleural mesothelioma with immunohistochemical staining positive for Krebs von den Lungen-6

A 71-year-old male visited a hospital with a chief complaint of exertional dyspnea. A chest CT revealed multiple nodular lesions on the parietal pleura. Thoracoscopic pleural biopsy was performed resulting in a diagnosis of pleural mesothelioma with epithelioid type. When chemotherapy was initially...

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Bibliographic Details
Published in:Respiratory medicine case reports 2024, Vol.50, p.102040-102040
Main Authors: Matsumura, Yugo, Sato, Seidai, Haji, Keiko, Masuda, Takeshi, Yoneda, Hiroto, Ogino, Hirokazu, Ogawa, Hirohisa, Hanibuchi, Masaki, Hattori, Noboru, Nishioka, Yasuhiko
Format: Report
Language:English
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Summary:A 71-year-old male visited a hospital with a chief complaint of exertional dyspnea. A chest CT revealed multiple nodular lesions on the parietal pleura. Thoracoscopic pleural biopsy was performed resulting in a diagnosis of pleural mesothelioma with epithelioid type. When chemotherapy was initially initiated, his serum level of Krebs von den Lungen-6 (KL-6) was high. However, once chemotherapy was started, the serum KL-6 level gradually decreased with tumor shrinkage. Immunohistochemical staining revealed the expression of KL-6 from the tumor cells. This is the first report of KL-6 production directly from tumor cells in epithelial-type pleural mesothelioma.
ISSN:2213-0071
2213-0071
DOI:10.1016/j.rmcr.2024.102040