A connection between phosphatidylinositol 5-phosphate and the Hippo pathway to prevent epithelial-mesenchymal transition in cancer

The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of , Palamiuc demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initia...

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Bibliographic Details
Published in:Science signaling 2024-05, Vol.17 (838), p.eadp3504
Main Authors: Hirsch, Emilio, Fantastico, Emanuele, Prever, Lorenzo, Gulluni, Federico
Format: Article
Language:English
Subjects:
Animals
Epithelial-Mesenchymal Transition
Hippo Signaling Pathway
Humans
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Phosphatidylinositol Phosphates - metabolism
Protein Serine-Threonine Kinases - genetics
Protein Serine-Threonine Kinases - metabolism
Signal Transduction
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of , Palamiuc demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP .
ISSN:1945-0877
1937-9145
1937-9145
DOI:10.1126/scisignal.adp3504