Natural product of angelica essential oil developed as a stable Pickering emulsion for joint interface lubrication

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2024-08, Vol.240, p.113993, Article 113993
• Main Authors: Wu, Qian, Yuan, Ziji, Fang, Ying, Wu, Liangbin, Bo, Zihan, Peng, Chengjun, Wu, Bo
• Format: Article
• Language: English
• Subjects: Angelica - chemistry; Angelica essential oil; Animals; Antioxidants - chemistry; Antioxidants - pharmacology; Biological lubricant; Biological Products - chemistry; Biological Products - pharmacology; Cell Survival - drug effects; Emulsions - chemistry; Graphite - chemistry; Graphite - pharmacology; Humans; Lubricants - chemistry; Lubricants - pharmacology; Lubrication; Lubrication mechanism; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Particle Size; Pickering emulsion; Surface Properties
• ISSN: 0927-7765; 1873-4367; 1873-4367
• DOI: 10.1016/j.colsurfb.2024.113993

Development of high-performance joint injection lubricants has become the focus in the field of osteoarthritis treatment. Herein, natural product of angelica essential oil combined with the graphene oxide were prepared to the stable Pickering emulsion as a biological lubricant. The tribological properties of the Pickering emulsion under different friction conditions were studied. The lubricating mechanism was revealed and the biological activities were evaluated. Results showed that the prepared Pickering emulsion displayed superior lubrication property at the Ti6Al4V biological material interface. The maximum friction reduction and anti-wear abilities of the Pickering emulsion were improved by 36% and 50% compared to water, respectively. This was primarily due to the action of the double-layer lubrication films composed of the graphene oxide and angelica essential oil molecules. It was worth noting that the friction reduction effect of the Pickering emulsion at the natural cartilage interface was higher about 19% than that of HA used in clinic for OA commonly. In addition, the Pickering emulsion also displayed antioxidant activity and cell biocompatibility, showing a good clinical application prospect in the future. [Display omitted] •Natural product angelica essential oil was developed to a stable Pickering emulsion.•Emulsion displayed superior lubrication property as a novel biological lubricant.•Unique lubrication mechanism of the double-layer lubrication films was proposed.•Good biological activities of the Pickering emulsion were discovered concurrently.