Feasibility of Hepatic Artery Infusion Chemotherapy for Colorectal Liver Metastasis in an Indian Setting

• Published in: Indian journal of surgical oncology 2024-05, Vol.15 (Suppl 2), p.275-280
• Main Authors: Sree Ganesh, B., Kazi, Mufaddal, Goel, Mahesh, Saklani, Avanish, De Souza, Ashwin, Devarmani, Sanjana, Gala, Kunal, Shetty, Nitin, Kulkarni, Suyash, Ramaswamy, Anant, Ostwal, Vikas, Bhargava, Prabhat, Patkar, Shraddha
• Format: Article
• Language: English
• Subjects: Medicine; Medicine & Public Health; Oncology; Original Article; Surgery; Surgical Oncology
• ISSN: 0975-7651; 0976-6952
• DOI: 10.1007/s13193-023-01871-0

Hepatic artery infusion chemotherapy (HAIC) is a popular treatment modality for the treatment of colorectal liver metastasis (CRLM). The aim of this study was to determine the feasibility of HAIC for high-risk resected CRLM delivered using repeated femoral puncture and delivering 5-fluorouracil infusional chemotherapy along with systemic adjuvant chemotherapy. The present study is a retrospective review of a prospectively maintained database. All patients who underwent HAIC for colorectal liver metastases between July 2022 and July 2023 were included. A total of 12 patients were included in the study of which 11 completed four sessions as planned. The median age was 47 (29–73) years with nine male (81%) and two female (18%) patients. Rectum ( n = 7, 63%) was the most common primary location. All patients received systemic chemotherapy with 5-fluorouracil-based regimens prior to HAIC (median 12 cycles). The median number of metastasis was 2 (1–8). Eight patients had metastasis in unilobar distribution (73%). On completion of HAIC treatment, nine patients (64%) were completely disease free with a median follow-up of 8 months. None of the patients experienced any immediate adverse events during or after completion of the procedure. Conventional HAIC comes with various challenges such as unavailability of the agent floxuridine and the specialized HAIC pump. Percutaneous HAIC has a lower chance of infection. The delivery of HAIC using repeated femoral punctures and 5FU chemotherapy was successful in over 90% of the patients making it a feasible option in the treatment of CRLM.