Risk factors for the long‐term persistent genitourinary toxicity after stereotactic body radiation therapy for localized prostate cancer: A single‐center, retrospective study of 306 patients

Objectives To identify risk factors for the long‐term persistent genitourinary toxicity (GUT) after stereotactic body radiation therapy (SBRT) for localized prostate cancer (PCa). Methods A total of 306 patients who underwent SBRT at our institution between March 2017 and April 2022 were retrospecti...

Full description

Saved in:
Bibliographic Details
Published in:International journal of urology 2024-09, Vol.31 (9), p.1022-1029
Main Authors: Tanabe, Kenji, Kobayashi, Shuichiro, Tamiya, Takashi, Konishi, Tsuzumi, Hinoto, Ryoichi, Tsukamoto, Nobuhiro, Kashiyama, Shiho, Eriguchi, Takahisa, Noro, Akira
Format: Article
Language:English
Subjects:
acute genitourinary toxicity
Age Factors
Aged
Aged, 80 and over
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate analysis
Prostate cancer
Prostatic Neoplasms - radiotherapy
Prostatic Neoplasms - surgery
Radiation Injuries - epidemiology
Radiation Injuries - etiology
Radiation therapy
Radiosurgery - adverse effects
Retrospective Studies
Risk Factors
stereotactic body radiation therapy
Time Factors
Toxicity
Urogenital System - radiation effects
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To identify risk factors for the long‐term persistent genitourinary toxicity (GUT) after stereotactic body radiation therapy (SBRT) for localized prostate cancer (PCa). Methods A total of 306 patients who underwent SBRT at our institution between March 2017 and April 2022 were retrospectively evaluated. SBRT was performed at 35 Gy in five fractions over 5 or 10 days. Factors related to the long‐term persistence of acute GUT after SBRT were analyzed. Results During the median follow‐up period of 39.1 months, 203 (66%) patients experienced any grade of acute GUT, which remained in 78 (26%) patients 6 months after SBRT. Multivariate analysis revealed that age ≥75 years was consistently a significant independent risk factor for any grade of acute GUT 6, 12, and 24 months after SBRT (hazard ratio [HR] 2.31, p = 0.010; HR 2.84, p = 0001; and HR 3.05, p = 0.009, respectively). Older age was not a significant risk factor for the development of grade ≥2 acute GUT. The duration of acute GUT was significantly longer in the older group than in the nonolder group (median duration = 234 vs. 61 days, p 
ISSN:0919-8172
1442-2042
1442-2042
DOI:10.1111/iju.15507