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Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma
Objective To compare the ability to depict MRI features of hepatobiliary agents in microvascular infiltration (MVI) of hepatocellular carcinoma (HCC) during different stages of dynamic enhancement MRI. Materials and methods A retrospective study included 111 HCC lesions scanned with either Gd-EOB-DT...
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| Published in: | Abdominal imaging 2024-07, Vol.49 (7), p.2242-2249 |
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| container_title | Abdominal imaging |
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| creator | Yao, Wei-Wei Zhang, Han-Wen Ma, Yu-Pei Lee, Jia-Min Lee, Rui-ting Wang, Yu-li Liu, Xiao-lei Shen, Xin-Ping Huang, Biao Lin, Fan |
| description | Objective
To compare the ability to depict MRI features of hepatobiliary agents in microvascular infiltration (MVI) of hepatocellular carcinoma (HCC) during different stages of dynamic enhancement MRI.
Materials and methods
A retrospective study included 111 HCC lesions scanned with either Gd-EOB-DTPA or Gd-BOPTA. All cases underwent multiphase dynamic contrast-enhanced scanning before surgery, including arterial phase (AP), portal venous phase (PVP), transitional phase (TP), delayed phase (DP), and hepatobiliary phase (HBP). Two abdominal radiologists independently evaluated MRI features of MVI in HCC, such as peritumoral hyperenhancement, incomplete capsule, non-smooth tumor margins, and peritumoral hypointensity. Finally, the results were reviewed by the third senior abdominal radiologist. Chi-square (χ
2
) Inspection for comparison between groups. P |
| doi_str_mv | 10.1007/s00261-024-04311-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3063463164</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3085754793</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-bf940b655f51eb51be25d69f07a75c7eea5c3bf06706ad663d189df738bf20f63</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEolXpC7BAltiwCYzjv9wluuKnUiskBGvLcca3rpI42E7VPgcvjHPTAmLBypbnO2fGc6rqJYW3FEC9SwCNpDU0vAbOKK3vnlSnDZOyBhDt07_uJ9V5SjcAQKWgtBHPqxPWtg3nip9WP_dhnE002d8iMZMZ7pNPJDiSr5HMGF2Io5ksrk_XOJscOj94E--JOeCUE_ET6XH2NvvpQK6-XhCHJi8RjyajtzHcmmSXwcSCOj_ktVeYVt3mZ3EYjmVrovVTGM2L6pkzQ8Lzh_Os-v7xw7f95_ryy6eL_fvL2jZC5rpzOw6dFMIJip2gHTailzsHyihhFaIRlnUOpAJpeilZT9td7xRrO9eAk-yserP5zjH8WDBlPfq0jmMmDEvSDCTjklHJC_r6H_QmLLGsa6VaoQRXO1aoZqPKr1OK6PQc_ViWpSnoNTW9paZLavqYmr4rolcP1ks3Yv9b8phRAdgGpFKaDhj_9P6P7S-vtaYW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3085754793</pqid></control><display><type>article</type><title>Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma</title><source>Springer Link</source><creator>Yao, Wei-Wei ; Zhang, Han-Wen ; Ma, Yu-Pei ; Lee, Jia-Min ; Lee, Rui-ting ; Wang, Yu-li ; Liu, Xiao-lei ; Shen, Xin-Ping ; Huang, Biao ; Lin, Fan</creator><creatorcontrib>Yao, Wei-Wei ; Zhang, Han-Wen ; Ma, Yu-Pei ; Lee, Jia-Min ; Lee, Rui-ting ; Wang, Yu-li ; Liu, Xiao-lei ; Shen, Xin-Ping ; Huang, Biao ; Lin, Fan</creatorcontrib><description>Objective
To compare the ability to depict MRI features of hepatobiliary agents in microvascular infiltration (MVI) of hepatocellular carcinoma (HCC) during different stages of dynamic enhancement MRI.
Materials and methods
A retrospective study included 111 HCC lesions scanned with either Gd-EOB-DTPA or Gd-BOPTA. All cases underwent multiphase dynamic contrast-enhanced scanning before surgery, including arterial phase (AP), portal venous phase (PVP), transitional phase (TP), delayed phase (DP), and hepatobiliary phase (HBP). Two abdominal radiologists independently evaluated MRI features of MVI in HCC, such as peritumoral hyperenhancement, incomplete capsule, non-smooth tumor margins, and peritumoral hypointensity. Finally, the results were reviewed by the third senior abdominal radiologist. Chi-square (χ
2
) Inspection for comparison between groups. P < 0.05 is considered statistically significant. Receiver operating characteristic (ROC) curve was used to evaluate correlation with pathology, and the area under the curve (AUC) and 95% confidence interval (95% CI) were calculated.
Results
Among the four MVI evaluation signs, Gd-BOPTA showed significant differences in displaying two signs in the HBP (P < 0.05:0.000, 0.000), while Gd-EOB-DTPA exhibited significant differences in displaying all four signs (P < 0.05:0.005, 0.006, 0.000, 0.002). The results of the evaluations of the two contrast agents in the DP phase with incomplete capsulation showed the highest correlation with pathology (AUC: 0.843, 0.761). By combining the four MRI features, Gd-BOPTA and Gd-EOB-DTPA have correlated significantly with pathology, and Gd-BOPTA is better (AUC: 0.9312vs0.8712).
Conclusion
The four features of hepatobiliary agent dynamic enhancement MRI demonstrate a good correlation with histopathological findings in the evaluation of MVI in HCC, and have certain clinical significance.</description><identifier>ISSN: 2366-0058</identifier><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-024-04311-x</identifier><identifier>PMID: 38824474</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - pathology ; Chi-square test ; Comparative analysis ; Contrast agents ; Contrast Media ; Correlation ; Female ; Gadolinium ; Gadolinium DTPA ; Gastroenterology ; Hepatobiliary ; Hepatocellular carcinoma ; Hepatology ; Humans ; Image Enhancement - methods ; Imaging ; Infiltration ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Meglumine - analogs & derivatives ; Metastases ; Microvasculature ; Microvessels - diagnostic imaging ; Microvessels - pathology ; Middle Aged ; Organometallic Compounds ; Pathology ; Radiology ; Retrospective Studies ; Statistical analysis</subject><ispartof>Abdominal imaging, 2024-07, Vol.49 (7), p.2242-2249</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-bf940b655f51eb51be25d69f07a75c7eea5c3bf06706ad663d189df738bf20f63</cites><orcidid>0000-0001-5731-7429</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38824474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yao, Wei-Wei</creatorcontrib><creatorcontrib>Zhang, Han-Wen</creatorcontrib><creatorcontrib>Ma, Yu-Pei</creatorcontrib><creatorcontrib>Lee, Jia-Min</creatorcontrib><creatorcontrib>Lee, Rui-ting</creatorcontrib><creatorcontrib>Wang, Yu-li</creatorcontrib><creatorcontrib>Liu, Xiao-lei</creatorcontrib><creatorcontrib>Shen, Xin-Ping</creatorcontrib><creatorcontrib>Huang, Biao</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><title>Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Objective
To compare the ability to depict MRI features of hepatobiliary agents in microvascular infiltration (MVI) of hepatocellular carcinoma (HCC) during different stages of dynamic enhancement MRI.
Materials and methods
A retrospective study included 111 HCC lesions scanned with either Gd-EOB-DTPA or Gd-BOPTA. All cases underwent multiphase dynamic contrast-enhanced scanning before surgery, including arterial phase (AP), portal venous phase (PVP), transitional phase (TP), delayed phase (DP), and hepatobiliary phase (HBP). Two abdominal radiologists independently evaluated MRI features of MVI in HCC, such as peritumoral hyperenhancement, incomplete capsule, non-smooth tumor margins, and peritumoral hypointensity. Finally, the results were reviewed by the third senior abdominal radiologist. Chi-square (χ
2
) Inspection for comparison between groups. P < 0.05 is considered statistically significant. Receiver operating characteristic (ROC) curve was used to evaluate correlation with pathology, and the area under the curve (AUC) and 95% confidence interval (95% CI) were calculated.
Results
Among the four MVI evaluation signs, Gd-BOPTA showed significant differences in displaying two signs in the HBP (P < 0.05:0.000, 0.000), while Gd-EOB-DTPA exhibited significant differences in displaying all four signs (P < 0.05:0.005, 0.006, 0.000, 0.002). The results of the evaluations of the two contrast agents in the DP phase with incomplete capsulation showed the highest correlation with pathology (AUC: 0.843, 0.761). By combining the four MRI features, Gd-BOPTA and Gd-EOB-DTPA have correlated significantly with pathology, and Gd-BOPTA is better (AUC: 0.9312vs0.8712).
Conclusion
The four features of hepatobiliary agent dynamic enhancement MRI demonstrate a good correlation with histopathological findings in the evaluation of MVI in HCC, and have certain clinical significance.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Chi-square test</subject><subject>Comparative analysis</subject><subject>Contrast agents</subject><subject>Contrast Media</subject><subject>Correlation</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA</subject><subject>Gastroenterology</subject><subject>Hepatobiliary</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Imaging</subject><subject>Infiltration</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meglumine - analogs & derivatives</subject><subject>Metastases</subject><subject>Microvasculature</subject><subject>Microvessels - diagnostic imaging</subject><subject>Microvessels - pathology</subject><subject>Middle Aged</subject><subject>Organometallic Compounds</subject><subject>Pathology</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><issn>2366-0058</issn><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhSMEolXpC7BAltiwCYzjv9wluuKnUiskBGvLcca3rpI42E7VPgcvjHPTAmLBypbnO2fGc6rqJYW3FEC9SwCNpDU0vAbOKK3vnlSnDZOyBhDt07_uJ9V5SjcAQKWgtBHPqxPWtg3nip9WP_dhnE002d8iMZMZ7pNPJDiSr5HMGF2Io5ksrk_XOJscOj94E--JOeCUE_ET6XH2NvvpQK6-XhCHJi8RjyajtzHcmmSXwcSCOj_ktVeYVt3mZ3EYjmVrovVTGM2L6pkzQ8Lzh_Os-v7xw7f95_ryy6eL_fvL2jZC5rpzOw6dFMIJip2gHTailzsHyihhFaIRlnUOpAJpeilZT9td7xRrO9eAk-yserP5zjH8WDBlPfq0jmMmDEvSDCTjklHJC_r6H_QmLLGsa6VaoQRXO1aoZqPKr1OK6PQc_ViWpSnoNTW9paZLavqYmr4rolcP1ks3Yv9b8phRAdgGpFKaDhj_9P6P7S-vtaYW</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Yao, Wei-Wei</creator><creator>Zhang, Han-Wen</creator><creator>Ma, Yu-Pei</creator><creator>Lee, Jia-Min</creator><creator>Lee, Rui-ting</creator><creator>Wang, Yu-li</creator><creator>Liu, Xiao-lei</creator><creator>Shen, Xin-Ping</creator><creator>Huang, Biao</creator><creator>Lin, Fan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5731-7429</orcidid></search><sort><creationdate>20240701</creationdate><title>Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma</title><author>Yao, Wei-Wei ; Zhang, Han-Wen ; Ma, Yu-Pei ; Lee, Jia-Min ; Lee, Rui-ting ; Wang, Yu-li ; Liu, Xiao-lei ; Shen, Xin-Ping ; Huang, Biao ; Lin, Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-bf940b655f51eb51be25d69f07a75c7eea5c3bf06706ad663d189df738bf20f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Chi-square test</topic><topic>Comparative analysis</topic><topic>Contrast agents</topic><topic>Contrast Media</topic><topic>Correlation</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA</topic><topic>Gastroenterology</topic><topic>Hepatobiliary</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Imaging</topic><topic>Infiltration</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meglumine - analogs & derivatives</topic><topic>Metastases</topic><topic>Microvasculature</topic><topic>Microvessels - diagnostic imaging</topic><topic>Microvessels - pathology</topic><topic>Middle Aged</topic><topic>Organometallic Compounds</topic><topic>Pathology</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Wei-Wei</creatorcontrib><creatorcontrib>Zhang, Han-Wen</creatorcontrib><creatorcontrib>Ma, Yu-Pei</creatorcontrib><creatorcontrib>Lee, Jia-Min</creatorcontrib><creatorcontrib>Lee, Rui-ting</creatorcontrib><creatorcontrib>Wang, Yu-li</creatorcontrib><creatorcontrib>Liu, Xiao-lei</creatorcontrib><creatorcontrib>Shen, Xin-Ping</creatorcontrib><creatorcontrib>Huang, Biao</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Wei-Wei</au><au>Zhang, Han-Wen</au><au>Ma, Yu-Pei</au><au>Lee, Jia-Min</au><au>Lee, Rui-ting</au><au>Wang, Yu-li</au><au>Liu, Xiao-lei</au><au>Shen, Xin-Ping</au><au>Huang, Biao</au><au>Lin, Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>49</volume><issue>7</issue><spage>2242</spage><epage>2249</epage><pages>2242-2249</pages><issn>2366-0058</issn><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Objective
To compare the ability to depict MRI features of hepatobiliary agents in microvascular infiltration (MVI) of hepatocellular carcinoma (HCC) during different stages of dynamic enhancement MRI.
Materials and methods
A retrospective study included 111 HCC lesions scanned with either Gd-EOB-DTPA or Gd-BOPTA. All cases underwent multiphase dynamic contrast-enhanced scanning before surgery, including arterial phase (AP), portal venous phase (PVP), transitional phase (TP), delayed phase (DP), and hepatobiliary phase (HBP). Two abdominal radiologists independently evaluated MRI features of MVI in HCC, such as peritumoral hyperenhancement, incomplete capsule, non-smooth tumor margins, and peritumoral hypointensity. Finally, the results were reviewed by the third senior abdominal radiologist. Chi-square (χ
2
) Inspection for comparison between groups. P < 0.05 is considered statistically significant. Receiver operating characteristic (ROC) curve was used to evaluate correlation with pathology, and the area under the curve (AUC) and 95% confidence interval (95% CI) were calculated.
Results
Among the four MVI evaluation signs, Gd-BOPTA showed significant differences in displaying two signs in the HBP (P < 0.05:0.000, 0.000), while Gd-EOB-DTPA exhibited significant differences in displaying all four signs (P < 0.05:0.005, 0.006, 0.000, 0.002). The results of the evaluations of the two contrast agents in the DP phase with incomplete capsulation showed the highest correlation with pathology (AUC: 0.843, 0.761). By combining the four MRI features, Gd-BOPTA and Gd-EOB-DTPA have correlated significantly with pathology, and Gd-BOPTA is better (AUC: 0.9312vs0.8712).
Conclusion
The four features of hepatobiliary agent dynamic enhancement MRI demonstrate a good correlation with histopathological findings in the evaluation of MVI in HCC, and have certain clinical significance.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38824474</pmid><doi>10.1007/s00261-024-04311-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5731-7429</orcidid></addata></record> |
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| subjects | Adult Aged Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - pathology Chi-square test Comparative analysis Contrast agents Contrast Media Correlation Female Gadolinium Gadolinium DTPA Gastroenterology Hepatobiliary Hepatocellular carcinoma Hepatology Humans Image Enhancement - methods Imaging Infiltration Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Meglumine - analogs & derivatives Metastases Microvasculature Microvessels - diagnostic imaging Microvessels - pathology Middle Aged Organometallic Compounds Pathology Radiology Retrospective Studies Statistical analysis |
| title | Comparative analysis of the performance of hepatobiliary agents in depicting MRI features of microvascular infiltration in hepatocellular carcinoma |
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