Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

• Published in: Advanced healthcare materials 2024-10, Vol.13 (27), p.e2401195-n/a
• Main Authors: Mamidi, Narsimha, De Silva, Fátima Franco, Vacas, Alejandro Bedón, Gutiérrez Gómez, Javier Adonay, Montes Goo, Naomi Yael, Mendoza, Daniela Ruiz, Reis, Rui L., Kundu, Subhas C.
• Format: Article
• Language: English
• Subjects: Amino acids; Biological properties; biomedical applications; Biomedical engineering; Biosensors; Cell adhesion; Cell proliferation; engineering novel hydrogels; environmental applications; Extracellular matrix; Food industry; functional hydrogels; Health care; Hydrogels; Metalloproteinase; Peptides; Physicochemical properties; Proteins; protein‐based scaffolds; Remediation; Scaffolds
• ISSN: 2192-2640; 2192-2659; 2192-2659
• DOI: 10.1002/adhm.202401195

Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic the extracellular matrix, promoting cell adhesion. Further enhancing cell proliferation within these scaffolds are matrix‐metalloproteinase‐triggered amino acid motifs. Integration of cell‐friendly modules like peptides and proteins expands hydrogel functionality. These exceptional properties position hydrogels for diverse applications, including biomedicine, biosensors, environmental remediation, and the food industry. Despite significant progress, there is ongoing research to optimize hydrogels for biomedical and environmental applications further. Engineering novel hydrogels with favorable characteristics is crucial for regulating tissue architecture and facilitating ecological remediation. This review explores the synthesis, physicochemical properties, and biological implications of various hydrogel types and their extensive applications in biomedicine and environmental sectors. It elaborates on their potential applications, bridging the gap between advancements in the healthcare sector and solutions for environmental issues. Multifaceted hydrogels mimic the extracellular matrix, promoting cell adhesion and proliferation via controlled amino acid motifs. Integration of peptides and proteins further expands their functionality. This review explores the synthesis, properties, and applications of these versatile hydrogels in biomedicine and environmental sectors (remediation, food industry). Despite progress, ongoing research focuses on optimizing hydrogels for tailored functions in both fields.