Exposure to BPA and BPS during pregnancy disrupts the bone mineralization in the offspring

Exposure to plastic-derived estrogen-mimicking endocrine-disrupting bisphenols can have a long-lasting effect on bone health. However, gestational exposure to bisphenol A (BPA) and its analogue, bisphenol S (BPS), on offspring's bone mineralization is unclear. The effects of in-utero bisphenol...

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Bibliographic Details
Published in:Food and chemical toxicology 2024-07, Vol.189, p.114772, Article 114772
Main Authors: Varma, Saikanth, Molangiri, Archana, Mudavath, Sreedhar, Ananthan, Rajendran, Rajanna, Ajumeera, Duttaroy, Asim K., Basak, Sanjay
Format: Article
Language:English
Subjects:
alkaline phosphatase
Alkaline Phosphatase - blood
Alkaline Phosphatase - metabolism
Animals
Benzhydryl Compounds - toxicity
bisphenol A
bisphenol S
Bisphenols
bone density
Bone Density - drug effects
bone health
Bone mineralization
Bone Morphogenetic Protein 1 - genetics
Bone Morphogenetic Protein 1 - metabolism
Bone Morphogenetic Protein 4 - genetics
Bone Morphogenetic Protein 4 - metabolism
Bone morphogenetic proteins
Calcification, Physiologic - drug effects
Carrier Proteins
Endocrine Disruptors - toxicity
extracellular matrix
Female
Humans
Male
maternal exposure
Maternal Exposure - adverse effects
mineralization
oral gavage
Osteoblast
osteoblasts
Osteoblasts - drug effects
Osteoblasts - metabolism
osteocalcin
Osteocalcin - genetics
Osteocalcin - metabolism
Phenols - toxicity
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
progeny
Rats
Rats, Wistar
Smad1 Protein - genetics
Smad1 Protein - metabolism
Sulfones - toxicity
TGF-β1
toxicology
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
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Summary:Exposure to plastic-derived estrogen-mimicking endocrine-disrupting bisphenols can have a long-lasting effect on bone health. However, gestational exposure to bisphenol A (BPA) and its analogue, bisphenol S (BPS), on offspring's bone mineralization is unclear. The effects of in-utero bisphenol exposure were examined on the offspring's bone parameters. BPA and BPS (0.0, 0.4 μg/kg bw) were administered to pregnant Wistar rats via oral gavage from gestational day 4–21. Maternal exposure to BPA and BPS increased bone mineral content and density in the offspring aged 30 and 90 days (P 
ISSN:0278-6915
1873-6351
1873-6351
DOI:10.1016/j.fct.2024.114772