Targeting TRPs in autophagy regulation and human diseases

Transient receptor potential channels (TRPs) are widely recognized as a group of ion channels involved in various sensory perceptions, such as temperature, taste, pressure, and vision. While macroautophagy (hereafter referred to as autophagy) is primarily regulated by core machinery, the ion exchang...

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Bibliographic Details
Published in:European journal of pharmacology 2024-08, Vol.977, p.176681, Article 176681
Main Authors: Yuan, Yongkang, Zhang, Qiuju, Qiu, Feng, Kang, Ning, Zhang, Qiang
Format: Article
Language:English
Subjects:
Autophagy
Cellular and molecular mechanisms
Disease targets
Human diseases
Transient receptor potential channels
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Summary:Transient receptor potential channels (TRPs) are widely recognized as a group of ion channels involved in various sensory perceptions, such as temperature, taste, pressure, and vision. While macroautophagy (hereafter referred to as autophagy) is primarily regulated by core machinery, the ion exchange mediated by TRPs between intracellular and extracellular compartments, as well as within organelles and the cytoplasm, plays a crucial role in autophagy regulation as an important signaling transduction mechanism. Moreover, certain TRPs can directly interact with autophagy regulatory proteins to participate in autophagy regulation. In this article, we provide an in-depth review of the current understanding of the regulatory mechanisms of autophagy, with a specific focus on TRPs. Furthermore, we highlight the potential prospects for drug development targeting TRPs in autophagy for the treatment of human diseases. [Display omitted]
ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2024.176681