Sclerosing well-differentiated liposarcoma: two diagnostically challenging mimicker cases and a literature review

Liposarcoma is a malignant soft tissue tumor with several subtypes, the most common of which is well-differentiated liposarcoma (WDL) or atypical lipomatous tumor (ALT). WDL/ALTs are further divided into three histological subtypes, including lipoma-like, sclerosing, and inflammatory. While the majo...

Full description

Saved in:
Bibliographic Details
Published in:Skeletal radiology 2025-02, Vol.54 (2), p.353-358
Main Authors: Noorily, Ariella R., Hoda, Syed T., Mantilla, Jose G., Samim, Mohammad
Format: Article
Language:English
Subjects:
Aged
Case Report
Diagnosis, Differential
Female
Fibrosis
Humans
Imaging
Lipoma
Liposarcoma
Liposarcoma - diagnostic imaging
Liposarcoma - pathology
Literature reviews
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Orthopedics
Pathology
Radiology
Sclerosis - diagnostic imaging
Soft Tissue Neoplasms - diagnostic imaging
Soft Tissue Neoplasms - pathology
Soft tissues
Tomography, X-Ray Computed
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liposarcoma is a malignant soft tissue tumor with several subtypes, the most common of which is well-differentiated liposarcoma (WDL) or atypical lipomatous tumor (ALT). WDL/ALTs are further divided into three histological subtypes, including lipoma-like, sclerosing, and inflammatory. While the majority of these tumors are predominantly fatty, the sclerosing variant demonstrates diverse histologic and radiographic characteristics, including variable amounts of fibrosis and fat. Because of this histological variability and relative rarity, the sclerosing WDL/ALT can present diagnostic dilemmas. We present two cases of sclerosing WDL/ALT, both of which demonstrated high degrees of fibrosis and a paucity of fat, mimicking desmoid fibromatosis and other fibrotic soft tissue tumors. Thus, it is important for radiologists to be aware of the subtypes of liposarcoma and their unique characteristics, and to consider sclerosing WDL/ALT in cases of fibrotic soft tissue tumors.
ISSN:0364-2348
1432-2161
1432-2161
DOI:10.1007/s00256-024-04716-1