Infectious and non-infectious precipitants of sarcoidosis

• Published in: Journal of autoimmunity 2024-12, Vol.149, p.103239, Article 103239
• Main Authors: Chioma, Ozioma S., Wiggins, ZaDarreyal, Rea, Samantha, Drake, Wonder P.
• Format: Article
• Language: English
• Subjects: Causes; Disease Susceptibility; Drugs; Environment; Ethnicity; Female; Gastrointestinal Microbiome - immunology; Genetic Predisposition to Disease; Genetics; Gut microbiome; Hormone; Humans; Immune system; Race; Risk Factors; Sarcoidosis; Sarcoidosis - diagnosis; Sarcoidosis - epidemiology; Sarcoidosis - etiology; Sarcoidosis - immunology; Sex
• ISSN: 0896-8411; 1095-9157; 1095-9157
• DOI: 10.1016/j.jaut.2024.103239

Sarcoidosis is a chronic inflammatory disease that can affect any organ in the body. Its exact cause remains unknown, but it is believed to result from a combination of genetic and environmental factors. Some potential causes of sarcoidosis include genetics, environmental triggers, immune system dysfunction, the gut microbiome, sex, and race/ethnicity. Genetic mutations are associated with protection against disease progression or an increased susceptibility to more severe disease, while exposure to certain chemicals, bacteria, viruses, or allergens can trigger the formation of immune cell congregations (granulomas) in different organs. Dysfunction of the immune system, including autoimmune reactions, may also contribute. The gut microbiome and factors such as being female or having African American, Scandinavian, Irish, or Puerto Rican heritage are additional contributors to disease outcome. Recent research has suggested that certain drugs, such as anti-Programmed Death-1 (PD-1) and antibiotics such as tuberculosis (TB) drugs, may raise the risk of developing sarcoidosis. Hormone levels, particularly higher levels of estrogen and progesterone in women, have also been linked to an increased likelihood of sarcoidosis. The diagnosis of sarcoidosis involves a comprehensive assessment that includes medical history, physical examination, laboratory tests, and imaging studies. While there is no cure for sarcoidosis, the symptoms can often be effectively managed through various treatment options. Treatment may involve the use of medications, surgical interventions, or lifestyle changes. These disparate factors suggests that sarcoidosis has multiple positive and negative exacerbants on disease severity, some of which can be ameliorated and others which cannot. •This work provides a detailed list of potential infectious causes.•This works provides a detailed list of non-infectious contributors.•A synopsis figures of potential drives of sarcoidosis progression is also included.