Prognostic role of SOX2 and STAT3 expression on circulating T lymphocytes and CD44+/CD24neg cells in the locally advanced and metastatic breast cancer

Background Breast cancer (BC) is associated with a continuous increase in incidence, with high mortality rates in several countries. CD44, STAT3, and SOX2 are related to regulating of somatic cell division, tumorigenesis, and metastasis in BC. Methods A cross‐sectional study was carried out at the H...

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Bibliographic Details
Published in:Journal of surgical oncology 2024-09, Vol.130 (4), p.669-680
Main Authors: Sobral, Denise V., Salgado, Marcelo R. T., Martins, Mario R., Vasconcelos, Carolina de S., Anunciação, Carlos E. C., Andrade, Victor P., Torres, Leuridan C.
Format: Article
Language:English
Subjects:
Breast cancer
Lymphatic system
Lymphocytes
Metastasis
SOX2
STAT3
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Summary:Background Breast cancer (BC) is associated with a continuous increase in incidence, with high mortality rates in several countries. CD44, STAT3, and SOX2 are related to regulating of somatic cell division, tumorigenesis, and metastasis in BC. Methods A cross‐sectional study was carried out at the Hospital de Cancer de Pernambuco (HCP) between 2017 and 2018. Fifty‐one women with locally advanced (LA) and 14 with metastatic BC were included in the study. Results High CD44+/CD24neg and CD44+/CD24neg/SOX2+ levels in Luminal B (LB), HER2+, and triple‐negative breast cancer (TNBC) compared with controls (p 
ISSN:0022-4790
1096-9098
1096-9098
DOI:10.1002/jso.27716