Nucleic acid-responsive smart systems for controlled cargo delivery

Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient delivery of various cargos while minimizing side effects. Owing to the unique properties of nucleic acids, including the ability to adopt complex structures by base pairing, their easy synthesis, high specificity,...

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Bibliographic Details
Published in:Biotechnology advances 2024-09, Vol.74, p.108393, Article 108393
Main Authors: Hasanzadeh, Akbar, Ebadati, Arefeh, Saeedi, Sara, Kamali, Babak, Noori, Hamid, Jamei, Behnam, Hamblin, Michael R., Liu, Yong, Karimi, Mahdi
Format: Article
Language:English
Subjects:
Aptamer targeting
Controlled release
CRISPR-responsive
NA-responsive
Smart delivery vehicle
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Summary:Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient delivery of various cargos while minimizing side effects. Owing to the unique properties of nucleic acids, including the ability to adopt complex structures by base pairing, their easy synthesis, high specificity, shape memory, and configurability, they have been employed in autonomous molecular motors, logic circuits, reconfigurable nanoplatforms, and catalytic amplifiers. Moreover, the development of nucleic acid (NA)-responsive intelligent delivery vehicles is a rapidly growing field. These vehicles have attracted much attention in recent years due to their programmable, controllable, and reversible properties. In this work, we review several types of NA-responsive controlled delivery vehicles based on locks and keys, including DNA/RNA-responsive, aptamer-responsive, and CRISPR-responsive, and summarize their advantages and limitations. [Display omitted]
ISSN:0734-9750
1873-1899
1873-1899
DOI:10.1016/j.biotechadv.2024.108393