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The relationship between bone health and type of intracranial internal carotid calcifications in patients with ischemic stroke
Vascular calcifications, primarily in the aorta and its proximal branches, are commonly observed among subjects with impaired bone health. In this study, we sought to determine if a comparable association holds true for the calcifications in the intracranial internal carotid arteries (IICA), in gene...
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| Published in: | Clinical neurology and neurosurgery 2024-08, Vol.243, p.108360, Article 108360 |
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| container_title | Clinical neurology and neurosurgery |
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| creator | Oge, Dogan Dinc Topcuoglu, Mehmet Akif Gultekin Zaim, Ozge Berna Gumeler, Ekim Arsava, Ethem Murat |
| description | Vascular calcifications, primarily in the aorta and its proximal branches, are commonly observed among subjects with impaired bone health. In this study, we sought to determine if a comparable association holds true for the calcifications in the intracranial internal carotid arteries (IICA), in general and also for particular calcification patterns.
A consecutive series of ischemic stroke patients were prospectively enrolled into the study, where computed tomography angiography source images were used to determine the presence and type of IICA calcifications, and dual-energy X-ray absorptiometry was used to determine the bone mineral density in the left femoral neck region. IICA calcifications were categorized as none, intimal, medial, and mixed types based on previously validated classification schemes. Their relationships with femoral bone T-scores were evaluated by bivariate and multivariate analyses.
Femoral neck T-score was highest among patients without any vascular calcifications (n=65), when compared to the bone density measures among patients with any type of calcification (n=185) (p |
| doi_str_mv | 10.1016/j.clineuro.2024.108360 |
| format | article |
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A consecutive series of ischemic stroke patients were prospectively enrolled into the study, where computed tomography angiography source images were used to determine the presence and type of IICA calcifications, and dual-energy X-ray absorptiometry was used to determine the bone mineral density in the left femoral neck region. IICA calcifications were categorized as none, intimal, medial, and mixed types based on previously validated classification schemes. Their relationships with femoral bone T-scores were evaluated by bivariate and multivariate analyses.
Femoral neck T-score was highest among patients without any vascular calcifications (n=65), when compared to the bone density measures among patients with any type of calcification (n=185) (p<0.001). After adjustment for age, gender, vascular risk factors, and serum biomarkers related to bone health, the T-score remained significantly associated only with the pattern of intimal calcification [OR 0.63 (0.42 – 0.95), p=0.028].
Our findings suggest that the intracranial vasculature, in particular the internal carotid arteries, is not immune to the interplay between suboptimal bone health and vascular calcifications. This association was most robust for an intimal type of IICA calcification pattern, while no such relationship could be demonstrated for other types of vascular calcifications.
•Patients with intracranial internal carotid artery calcifications have lower T-scores in the femoral neck region.•An intimal type of calcification was primarily related to impaired bone health.•The interplay between suboptimal bone health and vascular calcifications extends to the field of intracranial vasculature.</description><identifier>ISSN: 0303-8467</identifier><identifier>ISSN: 1872-6968</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2024.108360</identifier><identifier>PMID: 38833808</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Absorptiometry, Photon ; Aged ; Aged, 80 and over ; Algorithms ; Angiography ; Aorta ; Atherosclerosis ; Bone density ; Bone Density - physiology ; Bone Mineral Density ; Calcification ; Calcification (ectopic) ; Cardiovascular disease ; Carotid arteries ; Carotid artery ; Carotid Artery Diseases - complications ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery, Internal - diagnostic imaging ; Computed tomography ; Computed Tomography Angiography ; Consent ; Contrast agents ; Coronary vessels ; Creatinine ; Diabetes ; Dual energy X-ray absorptiometry ; Female ; Femur ; Femur Neck - diagnostic imaging ; Humans ; Hypertension ; Internal carotid artery ; Intimal calcification ; Ischemia ; Ischemic stroke ; Ischemic Stroke - diagnostic imaging ; Magnetic resonance imaging ; Male ; Medial calcification ; Medical imaging ; Middle Aged ; Older people ; Patients ; Population ; Prospective Studies ; Prostheses ; Risk factors ; Stroke ; Tomography ; Vascular Calcification - complications ; Vascular Calcification - diagnostic imaging ; Vein & artery diseases</subject><ispartof>Clinical neurology and neurosurgery, 2024-08, Vol.243, p.108360, Article 108360</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><rights>2024. Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-75473263350f675c5fa9498f2b611ababcda8a7f93090eea2f970320247fe77e3</cites><orcidid>0000-0002-7267-1431 ; 0000-0001-8103-4779</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38833808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oge, Dogan Dinc</creatorcontrib><creatorcontrib>Topcuoglu, Mehmet Akif</creatorcontrib><creatorcontrib>Gultekin Zaim, Ozge Berna</creatorcontrib><creatorcontrib>Gumeler, Ekim</creatorcontrib><creatorcontrib>Arsava, Ethem Murat</creatorcontrib><title>The relationship between bone health and type of intracranial internal carotid calcifications in patients with ischemic stroke</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>Vascular calcifications, primarily in the aorta and its proximal branches, are commonly observed among subjects with impaired bone health. In this study, we sought to determine if a comparable association holds true for the calcifications in the intracranial internal carotid arteries (IICA), in general and also for particular calcification patterns.
A consecutive series of ischemic stroke patients were prospectively enrolled into the study, where computed tomography angiography source images were used to determine the presence and type of IICA calcifications, and dual-energy X-ray absorptiometry was used to determine the bone mineral density in the left femoral neck region. IICA calcifications were categorized as none, intimal, medial, and mixed types based on previously validated classification schemes. Their relationships with femoral bone T-scores were evaluated by bivariate and multivariate analyses.
Femoral neck T-score was highest among patients without any vascular calcifications (n=65), when compared to the bone density measures among patients with any type of calcification (n=185) (p<0.001). After adjustment for age, gender, vascular risk factors, and serum biomarkers related to bone health, the T-score remained significantly associated only with the pattern of intimal calcification [OR 0.63 (0.42 – 0.95), p=0.028].
Our findings suggest that the intracranial vasculature, in particular the internal carotid arteries, is not immune to the interplay between suboptimal bone health and vascular calcifications. This association was most robust for an intimal type of IICA calcification pattern, while no such relationship could be demonstrated for other types of vascular calcifications.
•Patients with intracranial internal carotid artery calcifications have lower T-scores in the femoral neck region.•An intimal type of calcification was primarily related to impaired bone health.•The interplay between suboptimal bone health and vascular calcifications extends to the field of intracranial vasculature.</description><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Angiography</subject><subject>Aorta</subject><subject>Atherosclerosis</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Bone Mineral Density</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Cardiovascular disease</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Carotid Artery Diseases - complications</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery, Internal - 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Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oge, Dogan Dinc</au><au>Topcuoglu, Mehmet Akif</au><au>Gultekin Zaim, Ozge Berna</au><au>Gumeler, Ekim</au><au>Arsava, Ethem Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between bone health and type of intracranial internal carotid calcifications in patients with ischemic stroke</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2024-08</date><risdate>2024</risdate><volume>243</volume><spage>108360</spage><pages>108360-</pages><artnum>108360</artnum><issn>0303-8467</issn><issn>1872-6968</issn><eissn>1872-6968</eissn><abstract>Vascular calcifications, primarily in the aorta and its proximal branches, are commonly observed among subjects with impaired bone health. In this study, we sought to determine if a comparable association holds true for the calcifications in the intracranial internal carotid arteries (IICA), in general and also for particular calcification patterns.
A consecutive series of ischemic stroke patients were prospectively enrolled into the study, where computed tomography angiography source images were used to determine the presence and type of IICA calcifications, and dual-energy X-ray absorptiometry was used to determine the bone mineral density in the left femoral neck region. IICA calcifications were categorized as none, intimal, medial, and mixed types based on previously validated classification schemes. Their relationships with femoral bone T-scores were evaluated by bivariate and multivariate analyses.
Femoral neck T-score was highest among patients without any vascular calcifications (n=65), when compared to the bone density measures among patients with any type of calcification (n=185) (p<0.001). After adjustment for age, gender, vascular risk factors, and serum biomarkers related to bone health, the T-score remained significantly associated only with the pattern of intimal calcification [OR 0.63 (0.42 – 0.95), p=0.028].
Our findings suggest that the intracranial vasculature, in particular the internal carotid arteries, is not immune to the interplay between suboptimal bone health and vascular calcifications. This association was most robust for an intimal type of IICA calcification pattern, while no such relationship could be demonstrated for other types of vascular calcifications.
•Patients with intracranial internal carotid artery calcifications have lower T-scores in the femoral neck region.•An intimal type of calcification was primarily related to impaired bone health.•The interplay between suboptimal bone health and vascular calcifications extends to the field of intracranial vasculature.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38833808</pmid><doi>10.1016/j.clineuro.2024.108360</doi><orcidid>https://orcid.org/0000-0002-7267-1431</orcidid><orcidid>https://orcid.org/0000-0001-8103-4779</orcidid></addata></record> |
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| ispartof | Clinical neurology and neurosurgery, 2024-08, Vol.243, p.108360, Article 108360 |
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| subjects | Absorptiometry, Photon Aged Aged, 80 and over Algorithms Angiography Aorta Atherosclerosis Bone density Bone Density - physiology Bone Mineral Density Calcification Calcification (ectopic) Cardiovascular disease Carotid arteries Carotid artery Carotid Artery Diseases - complications Carotid Artery Diseases - diagnostic imaging Carotid Artery, Internal - diagnostic imaging Computed tomography Computed Tomography Angiography Consent Contrast agents Coronary vessels Creatinine Diabetes Dual energy X-ray absorptiometry Female Femur Femur Neck - diagnostic imaging Humans Hypertension Internal carotid artery Intimal calcification Ischemia Ischemic stroke Ischemic Stroke - diagnostic imaging Magnetic resonance imaging Male Medial calcification Medical imaging Middle Aged Older people Patients Population Prospective Studies Prostheses Risk factors Stroke Tomography Vascular Calcification - complications Vascular Calcification - diagnostic imaging Vein & artery diseases |
| title | The relationship between bone health and type of intracranial internal carotid calcifications in patients with ischemic stroke |
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