Fabrication of a self-healing hydrogel with antibacterial activity using host-guest interactions between dopamine-modified alginate and β-cyclodextrin dimer

Self-healing hydrogels possess an ability to recover their functionality after experiencing damage by regenerating cross-links. The main challenge in making self-healing hydrogels based on host-guest (HG) interactions is their limited mechanical strength, which can be solved using beta-cyclodextrin...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-07, Vol.273 (Pt 1), p.132827, Article 132827
Main Authors: Sadeghi, Moslem, Habibi, Younes, Bohlool, Tohid, Mohamadnia, Zahra, Nikfarjam, Nasser, Norouzi, Mastaneh
Format: Article
Language:English
Subjects:
Alginate-dopamine
Antibacterial
Cyclodextrin dimer
Host-guest interactions
Self-healing
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Summary:Self-healing hydrogels possess an ability to recover their functionality after experiencing damage by regenerating cross-links. The main challenge in making self-healing hydrogels based on host-guest (HG) interactions is their limited mechanical strength, which can be solved using beta-cyclodextrin dimers (β-CDsD). Here, β-CDsD as a host cross-linker was used to increase the mechanical property of the HG interactions. Alginate with acceptable biocompatibility was modified by dopamine (ALG-DOP) and employed as a guest polymer. Self-healing hydrogel was developed between them, and Ag nanoparticles were added to create an antibacterial activity. Dopamine with appropriate size and suitable adhesiveness established HG interactions with β-CDsD, and cells were able to grow well on hydrogel. This hydrogel showed an impressive self-healing capability
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.132827