Large-Scale Serological Survey of Influenza A Virus in South Korean Wild Boar (Sus scrofa)

In this comprehensive large-scale study, conducted from 2015 to 2019, 7,209 wild boars across South Korea were sampled to assess their exposure to influenza A viruses (IAVs). Of these, 250 (3.5%) were found to be IAV-positive by ELISA, and 150 (2.1%) by the hemagglutination inhibition test. Detected...

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Bibliographic Details
Published in:EcoHealth 2024-06, Vol.21 (2-4), p.174-182
Main Authors: Jung, Bud, Yeom, Minjoo, An, Dong-Jun, Kang, Aram, Vu, Thi Thu Hang, Na, Woonsung, Byun, Youngjoo, Song, Daesub
Format: Article
Language:English
Subjects:
Animals
Enzyme-Linked Immunosorbent Assay
Epizootics
Hemagglutination inhibition
Hemagglutination Inhibition Tests
Hogs
Humans
Influenza
Influenza A
Influenza A virus - immunology
Influenza A virus - isolation & purification
Influenza A Virus, H3N2 Subtype - isolation & purification
Orthomyxoviridae
Orthomyxoviridae Infections - epidemiology
Orthomyxoviridae Infections - veterinary
Orthomyxoviridae Infections - virology
Pandemics
Republic of Korea - epidemiology
Seroepidemiologic Studies
Sus scrofa
Sus scrofa - virology
Swine
Swine Diseases - epidemiology
Swine Diseases - virology
Viruses
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Summary:In this comprehensive large-scale study, conducted from 2015 to 2019, 7,209 wild boars across South Korea were sampled to assess their exposure to influenza A viruses (IAVs). Of these, 250 (3.5%) were found to be IAV-positive by ELISA, and 150 (2.1%) by the hemagglutination inhibition test. Detected subtypes included 23 cases of pandemic 2009 H1N1, six of human seasonal H3N2, three of classical swine H1N1, 13 of triple-reassortant swine H1N2, seven of triple-reassortant swine H3N2, and seven of swine-origin H3N2 variant. Notably, none of the serum samples tested positive for avian IAV subtypes H3N8, H5N3, H7N7, and H9N2 or canine IAV subtype H3N2. This serologic analysis confirmed the exposure of Korean wild boars to various subtypes of swine and human influenza viruses, with some serum samples cross-reacting between swine and human strains, indicating potential infections with multiple IAVs. The results highlight the potential of wild boar as a novel mixing vessel, facilitating the adaptation of IAVs and their spillover to other hosts, including humans. In light of these findings, we recommend regular and frequent surveillance of circulating influenza viruses in the wild boar population as a proactive measure to prevent potential human influenza pandemics and wild boar influenza epizootics.
ISSN:1612-9202
1612-9210
DOI:10.1007/s10393-024-01685-8