Single Method for Determination of Biocides Benzalkonium Chloride, Chloroxylenol and Chlorhexidine Gluconate in Cosmetics, Hygiene and Health Care Products by Using High Performance Liquid Chromatography

Benzalkonium chloride (BKC), chloroxylenol (PCMX) and chlorhexidine gluconate (CHG) are widely recognized biocidal compounds that require precise control and monitoring in various applications, including cosmetics, hygiene, health and ophthalmic products. In this study, we present a straightforward...

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Bibliographic Details
Published in:Journal of chromatographic science 2024-11, Vol.62 (9), p.837-844
Main Authors: Thangarathinam, Kumar, Narayanan, Meenakshi, Kumar Ks, Ashwin, Arjunan, Banupriya, Raja, Divya Bhavani
Format: Article
Language:English
Subjects:
Benzalkonium Compounds - analysis
Benzalkonium Compounds - chemistry
Chlorhexidine - analogs & derivatives
Chlorhexidine - analysis
Chromatography, High Pressure Liquid - methods
Cosmetics - analysis
Cosmetics - chemistry
Disinfectants - analysis
Disinfectants - chemistry
Limit of Detection
Linear Models
Reproducibility of Results
Xylenes - analysis
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Summary:Benzalkonium chloride (BKC), chloroxylenol (PCMX) and chlorhexidine gluconate (CHG) are widely recognized biocidal compounds that require precise control and monitoring in various applications, including cosmetics, hygiene, health and ophthalmic products. In this study, we present a straightforward and highly sensitive high-performance liquid chromatographic (HPLC) method for the detection of these substances. The HPLC method we developed allows for the detection of BKC at concentrations as low as 1.0 ppm, PCMX at 1.0 ppm and CHG at 2.0 ppm, all with a signal-to-noise (S/N) ratio exceeding 3.0. Additionally, the method enables quantification up to 2.0 ppm for BKC, 2.0 ppm for PCMX and 5 ppm for CHG, with an S/N ratio surpassing 10.0. This validated method serves as a versatile tool for the accurate quantification of BKC, PCMX and CHG in cosmetics, hygiene products, health products and ophthalmic products. Its applicability extends across a wide range of industries, ensuring the reliable assessment of these critical biocides.
ISSN:0021-9665
1945-239X
1945-239X
DOI:10.1093/chromsci/bmae039